Recombinant Mouse Dtnbp1 Protein, Myc/DDK-tagged
Cat.No. : | Dtnbp1-2672M |
Product Overview : | Purified recombinant protein of mouse full-length dystrobrevin binding protein 1 (Dtnbp1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Description : | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 39.7 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Dtnbp1 dystrobrevin binding protein 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Dtnbp1 |
Synonyms : | DTNBP1; dystrobrevin binding protein 1; dysbindin; sandy; dysbindin-1; HPS7 protein homolog; dystrobrevin-binding protein 1; hermansky-Pudlak syndrome 7 protein homolog; sdy; AW048963; 5430437B18Rik |
Gene ID : | 94245 |
mRNA Refseq : | NM_025772 |
Protein Refseq : | NP_080048 |
UniProt ID : | Q91WZ8 |
Products Types
◆ Recombinant Protein | ||
DTNBP1-1625R | Recombinant Rat DTNBP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Dtnbp1-682M | Recombinant Mouse Dtnbp1 Protein, His-tagged | +Inquiry |
DTNBP1-2902H | Recombinant Human DTNBP1 Protein, GST-tagged | +Inquiry |
Dtnbp1-683R | Recombinant Rat Dtnbp1 Protein, His-tagged | +Inquiry |
DTNBP1-2546M | Recombinant Mouse DTNBP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
DTNBP1-6796HCL | Recombinant Human DTNBP1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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