Recombinant Mouse Fgf1 Protein, His-tagged
| Cat.No. : | Fgf1-7205M |
| Product Overview : | Recombinant Mouse Fgf1 protein with a His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
| Description : | Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis. |
| Source : | E. coli |
| Species : | Mouse |
| Tag : | His |
| Form : | Liquid |
| Protein length : | 16-155 |
| AA Sequence : | MGSSHHHHHHSSGLVPRGSHMFNLP LGNYKKPKLLYCSNGGHFLRILPDG TVDGTRDRSDQHIQLQLSAESAGEV YIKGTETGQYLAMDTEGLLYGSQTP NEECLFLERLEENHYNTYTSKKHAE KNWFVGLKKNGSCKRGPRTHYGQKA ILFLPLPVSSD |
| Endotoxin : | < 1.0 EU/μg of protein (determined by LAL method) |
| Purity : | > 90 % |
| Stability : | Shelf life: one year from despatch. |
| Storage : | Store undiluted at 2-8 centigrade for up to two weeks or (in aliquots) at -20 or -70 centigrade for longer. Avoid repeated freezing and thawing. |
| Concentration : | 1.0 mg/mL (determined by Bradford assay) |
| Storage Buffer : | 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 30 % glycerol, 0.1 M NaCl |
| Gene Name : | Fgf1 fibroblast growth factor 1 [ Mus musculus (house mouse) ] |
| Official Symbol : | Fgf1 |
| Synonyms : | Fgf1; fibroblast growth factor 1; Fam; Fgf; Fgfa; Dffrx; Fgf-1; Fgf2b; fibroblast growth factor 1; HBGF-1; aFGF; acidic fibroblast growth factor; fibroblast growth factor 1 (acidic); fibroblast growth factor 2b; heparin-binding growth factor 1 |
| Gene ID : | 14164 |
| mRNA Refseq : | NM_010197 |
| Protein Refseq : | NP_034327 |
| UniProt ID : | P61148 |
Products Types
| ◆ Recombinant Protein | ||
| Fgf1-4096R | Active Recombinant Rat Fgf1 Protein | +Inquiry |
| Fgf1-056M | Active Recombinant Mouse Fgf1 Protein | +Inquiry |
| Fgf1-057M | Active Recombinant Mouse Fgf1 Protein | +Inquiry |
| FGF1-4094H | Recombinant Human FGF1 Protein, GST-tagged | +Inquiry |
| Fgf1-403F | Active Recombinant Mouse Fgf1 Protein (140 aa) | +Inquiry |
| ◆ Native Protein | ||
| FGF1-33B | Active Native Bovine FGF1 | +Inquiry |
| FGF1-26203TH | Native Human FGF1 | +Inquiry |
| ◆ Lysates | ||
| FGF1-6252HCL | Recombinant Human FGF1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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