Recombinant Mouse FGF18 protein(Met1-Gly207), His-tagged

• Cat.No.: Fgf18-491M
• Product Overview: Recombinant Mouse FGF18 (NP_032031.1) (Met 1-Gly 207) was expressed in HEK293, fused with a polyhistidine tag at the C-terminus.

Specification

• Source: HEK293
• Species: Mouse
• Tag: C-His
• Protein length: Met1-Gly207
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Bio-activity: 1. Measured by its binding ability in a functional ELISA. 2. Immobilized mouse FGF18 at 10 μg/mL (100 μl/well) can bind Rat FGFR4, The EC50 of Rat FGFR4 is 0.44 μg/mL.
• Molecular Mass: The secreted recombinant mouse FGF18 comprises 191 amino acids and has a predicted molecular mass of 22.5 kDa. As a result of glycosylation, it migrates as an approximately 30-35 kDa band in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: Fgf18 fibroblast growth factor 18 [ Mus musculus ]
• Official Symbol: FGF18
• Synonyms: FGF18; fibroblast growth factor 18; zFGF5; FGF-18; D130055P09Rik
• Gene ID: 14172
• mRNA Refseq: NM_008005
• Protein Refseq: NP_032031

Reviews

01/09/2022

the FGF18 protein exhibits remarkable stability, enabling it to maintain its structural integrity and functionality throughout the experimental process.

05/30/2021

The FGF18 protein offers exceptional quality and purity, which is crucial for ensuring reliable and reproducible experimental outcomes.

12/08/2017

As a researcher utilizing the FGF18 protein, I am fortunate to benefit from its numerous advantages in trials.

Q&As

What are the potential side effects of FGF18 therapy?

While generally considered safe, potential side effects may include local reactions at the injection site. Comprehensive studies are ongoing to assess long-term safety.

Is FGF18 only applicable to bone-related conditions?

While its primary focus is on musculoskeletal conditions, FGF18's role in cellular growth and repair suggests potential applications in other medical fields.

How does FGF18 compare to other growth factors in terms of clinical applications?

Comparative studies are underway to evaluate the effectiveness and safety of FGF18 against other growth factors in various clinical scenarios.

Are there any ongoing clinical trials involving FGF18?

Yes, there are several clinical trials exploring the safety and efficacy of FGF18 in various musculoskeletal disorders and conditions.

How does FGF18 contribute to the treatment of osteoarthritis?

FGF18 has shown promise in promoting cartilage repair and regeneration, making it a potential candidate for the development of therapies for osteoarthritis.