Recombinant Mouse Flt3 Protein, Myc/DDK-tagged
Cat.No. : | Flt3-3045M |
Product Overview : | Purified recombinant protein of mouse full-length FMS-like tyrosine kinase 3 (Flt3), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 113.9 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Flt3 FMS-like tyrosine kinase 3 [ Mus musculus (house mouse) ] |
Official Symbol : | Flt3 |
Synonyms : | FLT3; FMS-like tyrosine kinase 3; receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; fetal liver kinase 2; tyrosine-protein kinase FLT3; tyrosine-protein kinase receptor flk-2; Flk2; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04; MGC124377; MGC124378 |
Gene ID : | 14255 |
mRNA Refseq : | NM_010229 |
Protein Refseq : | NP_034359 |
UniProt ID : | Q00342 |
Products Types
◆ Recombinant Protein | ||
FLT3-4370H | Active Recombinant Human FLT3 Protein, GST-tagged | +Inquiry |
FLT3-98P | Active Recombinant Porcine FLT-3 Ligand Protein | +Inquiry |
FLT3-4371H | Recombinant Human FLT3 Protein, GST-tagged | +Inquiry |
FLT3-2340H | Recombinant Human FLT3 Protein, MYC/DDK-tagged | +Inquiry |
FLT3-97P | Active Recombinant Porcine FLT-3 Ligand Protein | +Inquiry |
◆ Lysates | ||
FLT3-2561HCL | Recombinant Human FLT3 cell lysate | +Inquiry |
FLT3-970MCL | Recombinant Mouse FLT3 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1592 | Flt3 ActivityAssay Kit | +Inquiry |
Kit-1593 | Flt3 Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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