Recombinant Mouse Gdf15 Protein, His-tagged

• Cat.No.: Gdf15-7379M
• Product Overview: Recombinant mouse GDF15 fused to His-tag at N-terminus, was expressed in E. coli.

Specification

• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation.
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Liquid
• Molecular Mass: 14.9 kDa
• Protein length: 189-303
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMGSSA HAHPRDSCPLGPGRCCHLETVQATL EDLGWSDWVLSPRQLQLSMCVGECP HLYRSANTHAQIKARLHGLQPDKVP APCCVPSSYTPVVLMHRTDSGVSLQ TYDDLVARGCHCA
• Purity: > 90 % by SDS-PAGE
• Stability: Shelf life: one year from despatch.
• Storage: Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing.
• Concentration: 1.0 mg/mL (determined by Bradford assay)
• Storage Buffer: 20 mM Phosphate buffer (pH 8.0) containing 10 % glycerol.

Gene Information

• Gene Name: Gdf15 growth differentiation factor 15 [ Mus musculus (house mouse) ]
• Official Symbol: Gdf15
• Synonyms: Gdf15; growth differentiation factor 15; NAG; SBF; MIC-; MIC-1; NAG-1; growth/differentiation factor 15; macrophage inhibiting cytokine-1; macrophage inhibitory cytokine 1
• Gene ID: 23886
• mRNA Refseq: NM_001330687
• Protein Refseq: NP_001317616
• UniProt ID: Q9Z0J7