Recombinant Mouse Hmbox1 Protein, Myc/DDK-tagged

• Cat.No.: Hmbox1-3409M
• Product Overview: Purified recombinant protein of mouse full-length homeobox containing 1 (cDNA clone MGC:56991 IMAGE:6398463), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 45.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Hmbox1 homeobox containing 1 [ Mus musculus (house mouse) ]
• Official Symbol: Hmbox1
• Synonyms: Hmbox1; homeobox containing 1; AI451877; AI604847; F830020C16Rik; homeobox-containing protein 1
• Gene ID: 219150
• mRNA Refseq: NM_177338
• Protein Refseq: NP_796312
• UniProt ID: Q8BJA3