Recombinant Mouse IDO1 Protein (1-407 aa), His-tagged

• Cat.No.: IDO1-2077M
• Product Overview: Recombinant Mouse IDO1 Protein (1-407 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Full Length.

Specification

• Description: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity (PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection.
• Source: Yeast
• Species: Mouse
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 47.6 kDa
• Protein length: 1-407 aa
• AA Sequence: MALSKISPTEGSRRILEDHHIDEDV GFALPHPLVELPDAYSPWVLVARNL PVLIENGQLREEVEKLPTLSTDGLR GHRLQRLAHLALGYITMAYVWNRGD DDVRKVLPRNIAVPYCELSEKLGLP PILSYADCVLANWKKKDPNGPMTYE NMDILFSFPGGDCDKGFFLVSLLVE IAASPAIKAIPTVSSAVERQDLKAL EKALHDIATSLEKAKEIFKRMRDFV DPDTFFHVLRIYLSGWKCSSKLPEG LLYEGVWDTPKMFSGGSAGQSSIFQ SLDVLLGIKHEAGKESPAEFLQEMR EYMPPAHRNFLFFLESAPPVREFVI SRHNEDLTKAYNECVNGLVSVRKFH LAIVDTYIMKPSKKKPTDGDKSEEP SNVESRGTGGTNPMTFLRSVKDTTE KALLSWP
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: Ido1 indoleamine 2,3-dioxygenase 1 [ Mus musculus ]
• Official Symbol: IDO1
• Synonyms: IDO1; indoleamine 2,3-dioxygenase 1; IDO-1; indole 2,3-dioxygenase; Ido; Indo
• Gene ID: 15930
• mRNA Refseq: NM_008324
• Protein Refseq: NP_032350
• UniProt ID: P28776