Recombinant Mouse Inpp4a Protein, Myc/DDK-tagged

• Cat.No.: Inpp4a-3544M
• Product Overview: Purified recombinant protein of mouse full-length inositol polyphosphate-4-phosphatase, type I (Inpp4a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate. Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 106 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Inpp4a inositol polyphosphate-4-phosphatase, type I [ Mus musculus (house mouse) ]
• Official Symbol: Inpp4a
• Synonyms: INPP4A; inositol polyphosphate-4-phosphatase, type I; type I inositol 3,4-bisphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type I; type I inositol-3,4-bisphosphate 4-phosphatase; 107kDa; R74740; 9630012D15; D130048C09Rik
• Gene ID: 269180
• mRNA Refseq: NM_030266
• Protein Refseq: NP_084542
• UniProt ID: Q9EPW0