Recombinant Mouse Ipmk Protein, Myc/DDK-tagged
Cat.No. : | Ipmk-3563M |
Product Overview : | Purified recombinant protein of mouse full-length inositol polyphosphate multikinase (Ipmk), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate. Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis. Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6). |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 44.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Ipmk inositol polyphosphate multikinase [ Mus musculus (house mouse) ] |
Official Symbol : | Ipmk |
Synonyms : | IPMK; inositol polyphosphate multikinase; inositol 1,3,4,6-tetrakisphosphate 5-kinase; Impk; AA408208; 2410017C19Rik |
Gene ID : | 69718 |
mRNA Refseq : | NM_027184 |
Protein Refseq : | NP_081460 |
UniProt ID : | Q7TT16 |
Products Types
◆ Recombinant Protein | ||
IPMK-1191H | Recombinant Human IPMK Protein, His (Fc)-Avi-tagged | +Inquiry |
IPMK-2743R | Recombinant Rat IPMK Protein, His (Fc)-Avi-tagged | +Inquiry |
IPMK-5079H | Recombinant Human IPMK Protein, GST-tagged | +Inquiry |
IPMK-4578M | Recombinant Mouse IPMK Protein, His (Fc)-Avi-tagged | +Inquiry |
IPMK-2442H | Recombinant Human IPMK Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
IPMK-866HCL | Recombinant Human IPMK cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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