Recombinant Mouse Itgb3 protein, His & S-tagged

• Cat.No.: Itgb3-6741M
• Product Overview: Recombinant Mouse Itgb3 aa. (Asp135~Ile377 (Accession # O54890)) fused with N-terminal His & S tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His & S
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 32.7kDa.
• Protein length: Asp135~Ile377 (Accession # O54890)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 5.7.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: Itgb3 integrin beta 3 [ Mus musculus (house mouse) ]
• Official Symbol: Itgb3
• Synonyms: CD61; GP3A; INGRB3; GPIIIa; platelet gpIIIa; platelet membrane glycoprotein IIIa; integrin beta-3
• Gene ID: 16416
• mRNA Refseq: NM_016780.2
• Protein Refseq: NP_058060.2
• UniProt ID: O54890

Reviews

02/06/2023

The technician modified my experimental protocol so that my experiment went smoothly.

11/14/2022

Very good after-sales service to get my experiments going!

04/01/2022

The protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.

Q&As

Where does ITGB3 exist?

ITGB3 is mainly found on the surface of PLT and megakaryocytes.

What are the biological functions of ITGB3?

ITGB3 is involved in the regulation of embryonic development, wound healing, coagulation and hemostasis, and immune response.

ITGB3 is closely associated with the study of which diseases?

ITGB3 is strongly associated with research into diseases such as colon and prostate cancer.

What are the subtypes of ITGB3?

There are two types of ITGB3, αvβ3 and αIIbβ3.

What are the consequences of ITGB3 deficiency?

ITGB3 deficiency led to reduced differentiation of circulating angiogenic cells, as well as reduced adhesion to the subendothelial membrane of injured endothelial cells, the unable to bind to fibrinogen, increasing the risk of vascular leakage or bleeding.