Recombinant Mouse Jaml Protein, Myc/DDK-tagged

• Cat.No.: Jaml-3631M
• Product Overview: Purified recombinant protein of mouse full-length junction adhesion molecule like (Jaml), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 42.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Jaml junction adhesion molecule like [ Mus musculus (house mouse) ]
• Official Symbol: Jaml
• Synonyms: Jaml; junction adhesion molecule like; Ami; AMICA; Crea7; Gm638; Amica1; junctional adhesion molecule-like; adhesion molecule AMICA; adhesion molecule, interacts with CXADR antigen 1; dendritic cell-specific protein CREA7; dendritic-cell specific protein Crea7; mCrea7
• Gene ID: 270152
• mRNA Refseq: NM_001005421
• Protein Refseq: NP_001005421
• UniProt ID: Q80UL9