Recombinant Mouse Kcne2 Protein, Myc/DDK-tagged

• Cat.No.: Kcne2-3655M
• Product Overview: Purified recombinant protein of mouse full-length potassium voltage-gated channel, Isk-related subfamily, gene 2 (Kcne2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 14.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Kcne2 potassium voltage-gated channel, Isk-related subfamily, gene 2 [ Mus musculus (house mouse) ]
• Official Symbol: Kcne2
• Synonyms: KCNE2; potassium voltage-gated channel, Isk-related subfamily, gene 2; potassium voltage-gated channel subfamily E member 2; minK-related peptide 1; potassium channel subunit beta MiRP1; minimum potassium ion channel related peptide 1; minimum potassium ion channel-related peptide 1; MiRP1; AW048273; 2200002I16Rik
• Gene ID: 246133
• mRNA Refseq: NM_134110
• Protein Refseq: NP_598871
• UniProt ID: Q9D808