| Description : |
Enables MHC class II protein binding activity and transmembrane signaling receptor activity. Involved in negative regulation of regulatory T cell differentiation; plasmacytoid dendritic cell activation; and regulation of immune response. Acts upstream of or within cell surface receptor signaling pathway; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). |
| Source : |
HEK293 |
| Species : |
Mouse |
| Form : |
Lyophilized |
| Molecular Mass : |
47.1 kDa |
| Protein Length : |
521 |
| AA Sequence : |
MREDLLLGFLLLGLLWEAPVVSSGP GKELPVVWAQEGAPVHLPCSLKSPN LDPNFLRRGGVIWQHQPDSGQPTPI PALDLHQGMPSPRQPAPGRYTVLSV APGGLRSGRQPLHPHVQLEERGLQR GDFSLWLRPALRTDAGEYHATVRLP NRALSCSLRLRVGQASMIASPSGVL KLSDWVLLNCSFSRPDRPVSVHWFQ GQNRVPVYNSPRHFLAETFLLLPQV SPLDSGTWGCVLTYRDGFNVSITYN LKVLGLEPVAPLTVYAAEGSRVELP CHLPPGVGTPSLLIAKWTPPGGGPE LPVAGKSGNFTLHLEAVGLAQAGTY TCSIHLQGQQLNATVTLAVITVTPK SFGLPGSRGKLLCEVTPASGKERFV WRPLNNLSRSCPGPVLEIQEARLLA ERWQCQLYEGQRLLGATVYAAESSS GAHSARRISGDLKGGHLVLVLILGA LSLFLLVAGAFGFHWWRKQLLLRRF SALEHGIQPFPAQRKIEELERELET EMGQEPEPEPEPQLEPEPRQL |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
