Recombinant Mouse LAIR1 protein, Mouse IgG2a Fc-tagged, low endotoxin
Cat.No. : | LAIR1-378M |
Product Overview : | Recombinant Mouse LAIR1 protein (Gln22-Tyr141)(low endotoxin), fused to Mouse IgG2a Fc tag at C-terminus, was expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell-mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism. |
Source : | HEK293 |
Species : | Mouse |
Tag : | Mouse IgG2a Fc |
Form : | Lyophilized from 0.22 um filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 40.6 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 120 |
Endotoxin : | Less than 0.1 EU per ug by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | LAIR1 |
Official Symbol : | LAIR1 |
Synonyms : | LAIR1; leukocyte-associated Ig-like receptor 1; leukocyte-associated immunoglobulin-like receptor 1; mLAIR1; Lair-1; mLair-1; BB115266; D7Bwg0421e; 5133400O11Rik |
Gene ID : | 52855 |
mRNA Refseq : | NM_001113474 |
Protein Refseq : | NP_001106945 |
UniProt ID : | Q8BG84 |
Products Types
◆ Recombinant Protein | ||
LAIR1-3325H | Recombinant Human LAIR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
LAIR1-3001R | Recombinant Rat LAIR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
LAIR1-092H | Recombinant Human LAIR1 Protein, C-His-tagged | +Inquiry |
Lair1-1728M | Recombinant Mouse Lair1 Protein, His-tagged | +Inquiry |
LAIR1-091H | Recombinant Human LAIR1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
LAIR1-1331MCL | Recombinant Mouse LAIR1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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