Recombinant Mouse LOXL2 Protein (26-776 aa), His-tagged

• Cat.No.: LOXL2-1447M
• Product Overview: Recombinant Mouse LOXL2 Protein (26-776 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Full Length of Mature Protein.

Specification

• Description: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in Extracellular domain matrix, promotes cross-linking of Extracellular domain matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (T) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 . Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.1 Publication
• Source: Yeast
• Species: Mouse
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 86.4 kDa
• Protein length: 26-776 aa
• AA Sequence: QYEGWPYQLQYPEYFQQPAPEHHQR QVPSDVVKIQVRLAGQKRKHNEGRV EVYYEGQWGTVCDDDFSIHAAHVVC RQVGYVEAKSWAASSSYGPGEGPIW LDNIYCTGKESTLASCSSNGWGVTD CKHTEDVGVVCSEKRIPGFKFDNSL INQIESLNIQVEDIRIRPILSAFRH RKPVTEGYVEVKEGKAWKQICNKHW TAKNSHVVCGMFGFPAEKTYNPKAY KTFASRRKLRYWKFSMNCTGTEAHI SSCKLGPSVTRDPVKNATCENGQPA VVSCVPSQIFSPDGPSRFRKAYKPE QPLVRLRGGAQVGEGRVEVLKNGEW GTICDDKWDLVSASVVCRELGFGTA KEAITGSRLGQGIGPIHLNEVQCTG TEKSIIDCKFNTESQGCNHEEDAGV RCNIPIMGFQKKVRLNGGRNPYEGR VEVLTERNGSLVWGTVCGQNWGIVE AMVVCRQLGLGFASNAFQETWYWHG NIFANNVVMSGVKCSGTELSLAHCR HDEEVACPEGGVRFGAGVACSETAP DLVLNAEIVQQTAYLEDRPMSLLQC AMEENCLSASAVHTDPTRGHRRLLR FSSQIHNNGQSDFRPKNGRHAWIWH DCHRHYHSMEVFTYYDLLSLNGTKV AEGHKASFCLEDTECEGDIQKSYEC ANFGEQGITMGCWDMYRHDIDCQWI DITDVPPGDYLFQVVINPNYEVPES DFSNNIMKCRSRYDGYRIWMYNCHV GGAFSEETEQKFEHFSGLLNNQLSV Q
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: Loxl2 lysyl oxidase-like 2 [ Mus musculus ]
• Official Symbol: LOXL2
• Synonyms: LOXL2; lysyl oxidase-like 2; 1110004B06Rik; 4930526G11Rik; 9430067E15Rik; MGC102220
• Gene ID: 94352
• mRNA Refseq: NM_033325
• Protein Refseq: NP_201582
• UniProt ID: P58022