| Description : |
Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. |
| Species : |
Mouse |
| Tag : |
His |
| Form : |
Liquid |
| Molecular Mass : |
72.6 kDa |
| Protein length : |
21-654 |
| AA Sequence : |
LPAPEKFVKDIDGGIDQDIFDINQG LGLDLFEGDIKLEANGKNSIIGDHK RWPHTIPYVLEDSLEMNAKGVILNA FERYRLKTCIDFKPWSGEANYISVF KGSGCWSSVGNIHAGKQELSIGTNC DRIATVQHEFLHALGFWHEQSRADR DDYVIIVWDRIQPGKEHNFNIYNDS VSDSLNVPYDYTSVMHYSKTAFQNG TESTIVTRISEFEDVIGQRMDFSDY DLLKLNQLYNCTSSLSFMDSCDFEL ENICGMIQSSGDSADWQRVSQVLSG PESDHSKMGQCKDSGFFMHFNTSIL NEGATAMLESRLLYPKRGFQCLEFY LYNSGSGNDQLNIYTREYTTGQQGG VLTLQRQIKEVPIGSWQLHYVTLQV TKKFRVVFEGLRGPGTSSGGLSIDD INLSETRCPHHIWHIQNFTQILGGQ DTSVYSPPFYSSKGYAFQIYMDLRS STNVGIYFHLISGANDDQLQWPCPW QQATMTLLDQNPDIRQRMFNQRSIT TDPTMTSDNGSYFWDRPSKVGVTDV FPNGTQFSRGIGYGTTVFITRERLK SREFIKGDDIYILLTVEDISHLNST SAVPDPVPTLAVHNACSEVVCQNGG ICVVQDGRAECKCPAGEDWWYMGKR CEKRGSTRDVEHHHHHH |
| Endotoxin : |
< 1.0 EU/μg of protein (determined by LAL method) |
| Purity : |
> 90 % by SDS-PAGE |
| Stability : |
Shelf life: one year from despatch. |
| Storage : |
Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing. |
| Concentration : |
0.25 mg/mL (determined by absorbance at 280nm) |
| Storage Buffer : |
Phosphate Buffered Saline (pH 7.4) containing 10 % glycerol. |
