Recombinant Mouse Mmp13 protein, His-tagged

• Cat.No.: Mmp13-731M
• Product Overview: Recombinant Mouse Mmp13 aa. (Val66~Gly238 (Accession# P33435)) fused with N-terminal His tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 21.0kDa
• Protein length: Val66~Gly238 (Accession# P33435)
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >90%
• Characteristic: The isoelectric point is 5.7.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in 10mM PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and preservative.
• Reconstitution: Reconstitute in sterile ddH2O.

Gene Information

• Gene Name: Mmp13 matrix metallopeptidase 13 [ Mus musculus (house mouse) ]
• Official Symbol: Mmp13
• Synonyms: Clg; Mmp1; MMP-13; collagenase-1; interstitial collagenase; matrix metalloproteinase 13
• Gene ID: 17386
• mRNA Refseq: NM_008607.2
• Protein Refseq: NP_032633.1
• UniProt ID: P33435

Reviews

12/05/2022

Its reliability and versatility make it an essential tool for investigating MMP13 protein's expression, function, and structural characteristics.

07/27/2020

The use of MMP13 protein in this technique allows researchers to explore the intricate three-dimensional structure of the protein at a molecular level.

10/13/2016

MMP13 protein is highly recommended for researchers due to its excellent performance in WB experiments and its utility in protein electron microscopy structure analysis.

Q&As

Can MMP13 be a potential therapeutic target for cancer treatment?

Yes, targeting MMP13 has been explored as a potential therapeutic strategy to inhibit cancer metastasis and invasion.

Is MMP13 involved in cardiovascular diseases?

Yes, MMP13 has been implicated in cardiovascular diseases by contributing to the remodeling of blood vessels and cardiac tissues.

How does MMP13 contribute to cancer progression?

MMP13 facilitates tumor invasion and metastasis by breaking down the extracellular matrix and promoting the migration of cancer cells.

How is genetic variation in MMP13 associated with disease susceptibility?

Certain genetic variations in the MMP13 gene have been linked to increased susceptibility to diseases such as osteoarthritis and cancer.

Are there any clinical trials targeting MMP13?

Some clinical trials are investigating drugs that specifically target MMP13 in various cancer types to assess their efficacy and safety.