Recombinant Mouse Msln Protein, Asp298-Ser600, C-His tagged, Biotinylated

• Cat.No.: Msln-267M
• Product Overview: Recombinant mouse MSLN/Mesothelin-C-His protein was developed from HEK293 and has a target region of C-His.

Specification

• Description: Predicted to be involved in cell-matrix adhesion. Predicted to act upstream of or within cell adhesion. Located in extracellular space. Is expressed in several structures, including body cavity or lining; genitourinary system; gut; heart; and respiratory system. Human ortholog(s) of this gene implicated in ovarian cancer; pancreas disease; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human MSLN (mesothelin).
• Source: HEK293
• Species: Mouse
• Tag: C-His
• Protein length: Asp298-Ser600
• Conjugation/Label: Biotin
• Form: Lyophilised
• Endotoxin: Endotoxin level was found to be less than 0.1 ng/μg (1 EU/μg).
• Notes: FOR RESEARCH USE ONLY (RUO).
• Storage: The lyophilized protein is stable for at least 1 year from date of receipt at -20 centigrade.
• Storage Buffer: Lyophilised from 0.2 μm filtered PBS solution pH 7.4. Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20 sec, 5K RPM

Gene Information

• Gene Name: Msln mesothelin [ Mus musculus ]
• Official Symbol: Msln
• Synonyms: MSLN; mesothelin; megakaryocyte potentiating factor; pre-pro-megakaryocyte-potentiating factor; MPF
• Gene ID: 56047
• mRNA Refseq: NM_018857
• Protein Refseq: NP_061345
• UniProt ID: Q61468

Reviews

05/22/2022

Very satisfied, great product.

03/06/2022

Product is high-quality.

09/30/2021

Excellent for experiments, reliable.

Q&As

What is the primary role of MSLN in normal tissues?

MSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.

How is MSLN expression altered in cancerous cells?

In cancer, MSLN expression is significantly upregulated.

In which types of cancer is MSLN overexpressed?

MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.

Are there any therapeutic strategies targeting MSLN in cancer treatment?

Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.

How can MSLN levels be detected and measured in clinical settings?

MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.

What is the prognostic significance of MSLN overexpression in cancer patients?

MSLN overexpression is often associated with poor prognosis in cancer patients.

How does MSLN contribute to cancer progression and metastasis?

MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.