Recombinant Mouse Notch2 Protein, His-tagged

• Cat.No.: Notch2-1838M
• Product Overview: Recombinant Mouse Notch2 Protein (Leu26-Phe294) with N-His tag was expressed in E. coli.

Specification

• Description: Enables NF-kappaB binding activity and enzyme binding activity. Involved in several processes, including heart looping; left/right axis specification; and marginal zone B cell differentiation. Acts upstream of or within several processes, including animal organ development; cholangiocyte proliferation; and positive regulation of BMP signaling pathway. Located in cilium and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Hajdu-Cheney syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2).
• Source: E. coli
• Species: Mouse
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 32.8 kDa
  Accurate Molecular Mass: 31 kDa
• Protein length: Leu26-Phe294
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: Notch2 Notch gene homolog 2 (Drosophila) [ Mus musculus (house mouse) ]
• Official Symbol: Notch2
• Synonyms: NOTCH2; Notch gene homolog 2 (Drosophila); neurogenic locus notch homolog protein 2; Motch B; notch 2; N2; AI853703
• Gene ID: 18129
• mRNA Refseq: NM_010928
• Protein Refseq: NP_035058
• UniProt ID: O35516