Recombinant Mouse Nudt16l1 Protein, Myc/DDK-tagged
Cat.No. : | Nudt16l1-4537M |
Product Overview : | Purified recombinant protein of mouse full-length nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 (cDNA clone MGC:35707 IMAGE:5322456),, with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs). Binds U8 snoRNA. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 16.7 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Nudt16l1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Nudt16l1 |
Synonyms : | Nudt16l1; nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1; Sdos; 1110001K21Rik; 5330437I08Rik; tudor-interacting repair regulator protein; NUDT16-like protein 1; protein syndesmos |
Gene ID : | 66911 |
mRNA Refseq : | NM_025839 |
Protein Refseq : | NP_080115 |
UniProt ID : | Q8VHN8 |
Products Types
◆ Recombinant Protein | ||
NUDT16L1-6251M | Recombinant Mouse NUDT16L1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NUDT16L1-6344C | Recombinant Chicken NUDT16L1 | +Inquiry |
NUDT16L1-959H | Recombinant Human NUDT16L1, His-tagged | +Inquiry |
NUDT16L1-10967M | Recombinant Mouse NUDT16L1 Protein | +Inquiry |
NUDT16L1-31391TH | Recombinant Human NUDT16L1, His-tagged | +Inquiry |
◆ Lysates | ||
NUDT16L1-3650HCL | Recombinant Human NUDT16L1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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