Recombinant Mouse Pan2 Protein, MYC/DDK-tagged
Cat.No. : | Pan2-224M |
Product Overview : | Purified recombinant protein of full-length mouse PAN2 poly(A) specific ribonuclease subunit (Pan2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. |
Source : | HEK293T |
Species : | Mouse |
Tag : | MYC/DDK |
Molecular Mass : | 135.3 kDa |
Purity : | >80%, as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Pan2 PAN2 poly(A) specific ribonuclease subunit [ Mus musculus (house mouse) ] |
Official Symbol : | Pan2 |
Synonyms : | Pan2; PAN2 poly(A) specific ribonuclease subunit; Usp52; AI047843; AW742773; mKIAA0710; 1200014O24Rik; PAN2-PAN3 deadenylation complex catalytic subunit Pan2; AN2 polyA specific ribonuclease subunit homolog; PAB-dependent poly(A)-specific ribonuclease subunit 2; PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2; PAN2 polyA specific ribonuclease subunit homolog; inactive ubiquitin carboxyl-terminal hydrolase 52; poly(A)-nuclease deadenylation complex subunit 2; ubiquitin specific peptidase 52; ubiquitin specific protease 52; EC 3.1.13.4 |
Gene ID : | 103135 |
mRNA Refseq : | NM_133992 |
Protein Refseq : | NP_598753 |
UniProt ID : | Q8BGF7 |
Products Types
◆ Recombinant Protein | ||
PAN2-6482M | Recombinant Mouse PAN2 Protein, His (Fc)-Avi-tagged | +Inquiry |
PAN2-3927R | Recombinant Rat PAN2 Protein, His (Fc)-Avi-tagged | +Inquiry |
PAN2-2165C | Recombinant Chicken PAN2 | +Inquiry |
PAN2-12331M | Recombinant Mouse PAN2 Protein | +Inquiry |
PAN2-4265R | Recombinant Rat PAN2 Protein | +Inquiry |
◆ Lysates | ||
PAN2-3446HCL | Recombinant Human PAN2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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