Recombinant Mouse Parp1 Protein, His-tagged

• Cat.No.: Parp1-358M
• Product Overview: Recombinant Mouse Parp1(Lys661~Pro881) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: Parp1 played an important role in many functions.
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 29.0kDa
• Identity: Reconstitute in PBS or others
• Protein length: Lys661~Pro881
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others

Gene Information

• Gene Name: Parp1 poly (ADP-ribose) polymerase family, member 1 [ Mus musculus ]
• Official Symbol: Parp1
• Synonyms: PARP1; poly (ADP-ribose) polymerase family, member 1; poly [ADP-ribose] polymerase 1; msPARP; ADPRT 1; poly[ADP-ribose] synthase 1; poly[ADP-ribose] synthetase 1; NAD(+) ADP-ribosyltransferase 1; ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1; PARP; PPOL; Adprp; Adprt1; C80510; parp-1; sPARP-1; AI893648; 5830444G22Rik
• Gene ID: 11545
• mRNA Refseq: NM_007415
• Protein Refseq: NP_031441

Reviews

06/01/2020

This range of applications of PARP1 is breathtaking, and it can play an important role in any field.

12/02/2019

This short half-life and high clearance of PARP1 make it have greater potential in the treatment of tumors, infections and other diseases, and it is expected to become a new generation of therapeutic drugs.

03/18/2019

The purity and bioactivity of PARP1 make it a valuable resource for scientific research.

Q&As

Does PARP1 protein cause cells to die in time?

Yes, overactivation of the PARP1 protein can lead to apoptosis or necrosis of cells, which may be exploited in the treatment of certain diseases.

How is the PARP1 protein involved in DNA repair?

The PARP1 protein can repair DNA damage by attaching ADP-ribose groups to damaged DNA strands and recruiting other repair proteins.

What are the other regulatory mechanisms of PARP1 protein in DNA damage repair?

In addition to PARP1's involvement in direct DNA repair, it can also modulate the selection of repair pathways and initiate other DNA damage sensing mechanisms.

What is the potential of PARP1 protein in tumor immunotherapy?

Some studies have proposed that the interaction of PARP1 protein with DNA damage in tumor immunotherapy may affect the efficacy of immunotherapy.

Is PARP1 protein involved in cell cycle regulation?

Yes, the PARP1 protein is involved in the normal regulation of the cell cycle, especially G1/S and G2/M switching during DNA damage.

What are the effects of overactivation of PARP1 protein on cells?

Overactivation of PARP1 depletes energy stores such as NAD+ and ATP and leads to apoptosis, or cell death.