Recombinant Mouse Ptpn6 protein(1-595aa), His-tagged

• Cat.No.: Ptpn6-8532M
• Product Overview: Recombinant Mouse Ptpn6 protein(P29351)(1-595aa), fused with N-terminal His tag, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Mouse
• Tag: N-His
• Protein length: 1-595aa
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 71.6 kDa
• AASequence: MVRWFHRDLSGPDAETLLKGRGVPG SFLARPSRKNQGDFSLSVRVDDQVT HIRIQNSGDFYDLYGGEKFATLTEL VEYYTQQQGILQDRDGTIIHLKYPL NCSDPTSERWYHGHISGGQAESLLQ AKGEPWTFLVRESLSQPGDFVLSVL NDQPKAGPGSPLRVTHIKVMCEGGR YTVGGSETFDSLTDLVEHFKKTGIE EASGAFVYLRQPYYATRVNAADIEN RVLELNKKQESEDTAKAGFWEEFES LQKQEVKNLHQRLEGQRPENKSKNR YKNILPFDHSRVILQGRDSNIPGSD YINANYVKNQLLGPDENSKTYIASQ GCLDATVNDFWQMAWQENTRVIVMT TREVEKGRNKCVPYWPEVGTQRVYG LYSVTNSREHDTAEYKLRTLQISPL DNGDLVREIWHYQYLSWPDHGVPSE PGGVLSFLDQINQRQESLPHAGPII VHCSAGIGRTGTIIVIDMLMESIST KGLDCDIDIQKTIQMVRAQRSGMVQ TEAQYKFIYVAIAQFIETTKKKLEI IQSQKGQESEYGNITYPPAVRSAHA KASRTSSKHKEEVYENVHSKSKKEE KVKKQRSADKEKNKGSLKRK
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C.

Gene Information

• Gene Name: Ptpn6 protein tyrosine phosphatase, non-receptor type 6 [ Mus musculus ]
• Official Symbol: Ptpn6
• Synonyms: PTPN6; protein tyrosine phosphatase, non-receptor type 6; tyrosine-protein phosphatase non-receptor type 6; PTP-1C; 70Z-SHP; SH-PTP1; PTPTY-42; hemopoietic cell phosphatase; protein-tyrosine phosphatase 1C; hematopoietic cell protein-tyrosine phosphatase; me; hcp; Hcph; Ptp1C; SHP-1; motheaten
• Gene ID: 15170
• mRNA Refseq: NM_001077705
• Protein Refseq: NP_001071173

Reviews

07/01/2020

Structural biology researchers can leverage its properties to better understand the three-dimensional architecture and conformational changes of proteins, gaining valuable insights into their function and interactions.

04/03/2018

PTPN6 protein is highly recommended for various research applications, including ELISA and protein electron microscopy structure analysis.

12/07/2017

PTPN6 protein might have biomarker properties, meaning its levels or activity could be indicative of disease progression or treatment response.

Q&As

How does PTPN6 function as a negative regulator in immune cells?

PTPN6 acts as a phosphatase, removing phosphate groups from specific tyrosine residues in signaling molecules, thereby downregulating immune cell activation.

Can PTPN6 be a potential target for immunotherapy?

Yes, PTPN6 modulation is being explored as a potential target for immunotherapies aimed at enhancing or suppressing immune responses based on the clinical context.

How does PTPN6 impact T cell signaling, and why is this important in clinical contexts?

PTPN6 negatively regulates T cell receptor signaling, and its modulation can have implications in controlling excessive immune responses seen in autoimmune diseases.

Are there specific diseases where the clinical application of PTPN6 is being investigated?

Yes, PTPN6 is being studied in diseases like rheumatoid arthritis, lupus, and certain types of leukemia and lymphoma.

In what ways can PTPN6 be targeted for therapeutic interventions?

Researchers are exploring small molecule inhibitors and gene therapies to modulate PTPN6 activity, with potential applications in autoimmune disorders and cancer treatment.