Recombinant Mouse Rad54l Protein, Myc/DDK-tagged
Cat.No. : | Rad54l-5352M |
Product Overview : | Purified recombinant protein of mouse full-length RAD54 like (S. cerevisiae) (Rad54l), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Description : | Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Plays also an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Deficiency also resulted in an increased frequency of end-to-end chromosome fusions involving telomeres compared to the controls, suggesting a putative role in telomere capping. Non-homologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. LIG4 and RAD54L cooperate to support cellular proliferation, repair spontaneous DSBs, and prevent chromosome and single chromatid aberrations. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 84.7 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Rad54l RAD54 like (S. cerevisiae) [ Mus musculus (house mouse) ] |
Official Symbol : | Rad54l |
Synonyms : | RAD54L; RAD54 like (S. cerevisiae); DNA repair and recombination protein RAD54-like; mHR54; mRAD54; RAD54 homolog; RAD54 |
Gene ID : | 19366 |
mRNA Refseq : | NM_001122958 |
Protein Refseq : | NP_001116430 |
UniProt ID : | P70270 |
Products Types
◆ Recombinant Protein | ||
RAD54L-1853H | Recombinant Human RAD54L Protein, His (Fc)-Avi-tagged | +Inquiry |
RAD54L-390H | Recombinant Human RAD54L Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
RAD54L-11363Z | Recombinant Zebrafish RAD54L | +Inquiry |
◆ Lysates | ||
RAD54L-2552HCL | Recombinant Human RAD54L 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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