Recombinant Mouse Rapgef6 Protein, Myc/DDK-tagged

• Cat.No.: Rapgef6-5379M
• Product Overview: Purified recombinant protein of mouse full-length Rap guanine nucleotide exchange factor (GEF) 6 (Rapgef6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Ubiquitous expression in thymus adult (RPKM 3.2), CNS E18 (RPKM 2.8) and 28 other tissues.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 179.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rapgef6 Rap guanine nucleotide exchange factor (GEF) 6 [ Mus musculus (house mouse) ]
• Official Symbol: Rapgef6
• Synonyms: RAPGEF6; Rap guanine nucleotide exchange factor (GEF) 6; rap guanine nucleotide exchange factor 2; PDZ domain containing guanine nucleotide exchange factor(GEF)1; PDZ domain containing guanine nucleotide exchange factor (GEF) 2; Ragef2; Pdzgef2; AI844632; BB085664; PDZ-GEF2; RA-GEF-2; mKIAA4052; A530068K01; C030018K18Rik; KIAA4052
• Gene ID: 192786
• mRNA Refseq: NM_175258
• Protein Refseq: NP_780467
• UniProt ID: Q3TKC6

Reviews

03/19/2022

the RAPGEF6 protein's high quality and its compatibility with my experimental needs, coupled with the manufacturer's excellent technical support, create a valuable alliance that contributes to successful research endeavors.

04/12/2020

The RAPGEF6 protein is characterized by its exceptional quality, making it an ideal choice to fulfill my experimental requirements.

04/19/2019

The manufacturer's commitment to providing high-quality proteins is evident in their meticulous production process, ensuring the purity and reliability of the RAPGEF6 protein.

Q&As

Are there any known animal models used to study RAPGEF6-related neurological disorders?

Animal models, such as mice with RAPGEF6 gene mutations, are being used to study the impact of RAPGEF6 dysfunction on neurological development and behavior.

How does RAPGEF6 protein function in neuronal development?

RAPGEF6 protein is involved in the regulation of neuronal differentiation, axon guidance, and synaptic plasticity, contributing to proper brain development and function.

Are there any therapeutic implications of RAPGEF6 protein in neurological conditions?

Targeting RAPGEF6 protein or its downstream signaling pathways may hold therapeutic potential for certain neurological conditions, but specific interventions are still under investigation.

What are the current diagnostic methods for detecting RAPGEF6 mutations?

Genetic testing, such as whole exome sequencing, is employed to identify mutations in the RAPGEF6 gene that may be linked to neurological disorders.

Are there any known interactions of RAPGEF6 with other proteins in the context of neurological disorders?

RAPGEF6 has been shown to interact with various proteins involved in synaptic transmission and neuronal signaling, suggesting potential implications in neurological disorders.