Recombinant Mouse Relb Protein, Myc/DDK-tagged
Cat.No. : | Relb-5457M |
Product Overview : | Purified recombinant protein of mouse full-length avian reticuloendotheliosis viral (v-rel) oncogene related B (Relb), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 60.3 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Relb avian reticuloendotheliosis viral (v-rel) oncogene related B [ Mus musculus (house mouse) ] |
Official Symbol : | Relb |
Synonyms : | RELB; avian reticuloendotheliosis viral (v-rel) oncogene related B; transcription factor RelB; shep; MGC143683; MGC143684 |
Gene ID : | 19698 |
mRNA Refseq : | NM_009046 |
Protein Refseq : | NP_033072 |
UniProt ID : | Q04863 |
Products Types
◆ Recombinant Protein | ||
RELB-1879H | Recombinant Human RELB Protein, His (Fc)-Avi-tagged | +Inquiry |
RELB-5321H | Recombinant Human RELB Protein, Myc/DDK-tagged | +Inquiry |
RELB-2561E | Recombinant Escherichia coli RELB Protein (1-79 aa), His-Myc-tagged | +Inquiry |
RELB-1852H | Recombinant Human RELB protein, His & T7-tagged | +Inquiry |
RELB-6167H | Recombinant Human RELB Protein (Asp248-Asp492), N-His tagged | +Inquiry |
◆ Lysates | ||
RELB-1493HCL | Recombinant Human RELB cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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