Recombinant Mouse Resistin, FLAG-tagged

• Cat.No.: Retn-197M
• Product Overview: Recombinant mouse resistin encoding the mature peptide (aa 21~114) of resistin was tagged with a FLAG peptide at the N-terminus. The tagged protein was expressed in a human embryonic kidney cell line,HEK293,and purified from conditioned media.

Specification

• Cat. No.: Retn-197M
• Description: Mouse resistin, specifically produced and secreted by adipocyte, acts on skeletal muscle myocytes, hepatocytes and adipocytes themselves so that it reduces their sensitivity to insulin. Steppan et al. have suggested that resistin suppresses the ability of insulin to stimulate glucose uptake. They have also suggested that resistin is present at elevated levels in blood of obese mice, and is down regulated by fasting and antidiabetic drugs. Way et al., on the other hand, have found that resistin expression is severly suppressed in obesity and is stimulated by several antidiabetic drugs. Other studies have shown that mouse resistin increases during the differentiation of adipocytes, but it also seems to inhibit adipogenesis. In contrast, the human adipogenic differentiation is likely to be associated with a down regulation of resistin gene expression.
• Source: HEK293.
• Formulation: 0.2 m filtered solution in phosphate buffered saline, pH 7.2.
• Purity: >95%, as determined by SDS-PAGE.
• Endotoxin Level: <0.1EU/g, as determined by the LAL method.
• Stability Storage And Handling: The protein solution should be stored in working aliquots at -20°C for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: Retn resistin [ Mus musculus ]
• Synonyms: Retn; resistin; ADSF; Rstn; Xcp4; Fizz3; found in inflammatory zone 3; adipocyte-specific secretory factor; rstn
• Gene ID: 57264
• mRNA Refseq: NM_022984
• Protein Refseq: NP_075360
• UniProt ID: Q99P87
• Chromosome Location: 8 A1; 8 0.37 cM
• Function: hormone activity

Reviews

06/22/2020

Catalytic activity of RETN is excellent, no matter what the environment can maintain stable catalytic performance, its reliability is reliable.

05/27/2020

The quality of RETN they produce is guaranteed, and we can buy it with confidence.

05/22/2019

The stability of RETN is too strong to ignore, and it remains admirably stable after long storage.

Q&As

How does the expression level of RETN correlate with insulin resistance?

Expression level of RETN is associated with the development of insulin resistance. High levels of RETN can reduce insulin sensitivity, leading to decreased glycemic control, which promotes the development of insulin resistance.

What is the role of RETN in the treatment of diabetes and cardiovascular disease?

Studies have shown that regulating the expression level of RETN can influence the development and treatment effect of diabetes and cardiovascular disease. For example, certain drugs can improve insulin sensitivity and control blood sugar levels by inhibiting the expression level of RETN.

How can the expression level of RETN be used for the prediction and diagnosis of diabetes and cardiovascular disease?

Diabetes and cardiovascular disease can be predicted and diagnosed by measuring the expression level of RETN. For example, high levels of RETN may indicate a higher risk of disease and more severe disease conditions.

How to use mutation or abnormal expression of RETN for disease diagnosis and prognosis assessment?

Mutations and expression levels of the RETN gene can be detected to aid in diagnosing disease and assessing prognosis. For example, certain mutations may predict a higher risk and a worse prognosis.

What diseases are mutations or abnormal expression of RETN associated with?

Mutations or abnormal expression of RETN may be associated with a variety of diseases. For example, certain mutations can lead to abnormally elevated levels of their expression, increasing the risk of diabetes, cardiovascular disease, etc.

How does RETN relate to other biomarkers?

RETN has some association with other biomarkers. For example, in obesity and cardiovascular disease, the expression level of RETN can be used to assess the prognosis and therapeutic effect of the disease together with biomarkers such as adiponectin and leptin.