Recombinant Mouse Rtkn Protein, His&GST-tagged

• Cat.No.: Rtkn-2035M
• Product Overview: Recombinant Mouse Rtkn Protein (Gln309-Phe416) with N-His&GST tag was expressed in E. coli.

Specification

• Description: Enables GTPase inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; cytoskeleton-dependent cytokinesis; and septin ring organization. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol. Predicted to be active in actomyosin contractile ring. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Orthologous to human RTKN (rhotekin).
• Source: E. coli
• Species: Mouse
• Tag: N-His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 42.2 kDa
  Accurate Molecular Mass: 40 kDa
• Protein length: Gln309-Phe416
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Rtkn rhotekin [ Mus musculus (house mouse) ]
• Official Symbol: Rtkn
• Synonyms: RTKN; rhotekin
• Gene ID: 20166
• mRNA Refseq: NM_001136227
• Protein Refseq: NP_001129699
• UniProt ID: Q8C6B2

Reviews

07/21/2022

They can offer specialized formulations, concentrations, or modifications of RTKN protein to suit unique experimental requirements.

03/23/2022

Collaborative discussions with the manufacturer can also help optimize experimental protocols and provide insights into the best practices in working with RTKN.

12/27/2021

The manufacturer can further support researchers by providing customized solutions tailored to their specific needs.

Q&As

Is RTKN a potential therapeutic target in cancer treatment?

Some studies propose RTKN as a potential therapeutic target for cancer, as inhibiting its activity may impede tumor progression.

How does RTKN contribute to cellular signaling pathways?

RTKN is known to modulate signaling pathways, including those associated with cell survival, proliferation, and differentiation.

How is RTKN linked to neurodegenerative diseases?

Some studies suggest that RTKN may be associated with neurodegenerative disorders, possibly influencing neuronal function.

Are there any known genetic mutations in the RTKN gene associated with diseases?

Genetic variations in the RTKN gene have been investigated for potential links to certain diseases, but more research is needed to establish clear associations.

Can RTKN be targeted for drug development?

The potential for developing drugs targeting RTKN is being explored, with a focus on its role in diseases such as cancer.