Recombinant Mouse Smarca5 Protein, Myc/DDK-tagged
Cat.No. : | Smarca5-5959M |
Product Overview : | Purified recombinant protein of mouse full-length SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (Smarca5), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 122.1 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 [ Mus musculus (house mouse) ] |
Official Symbol : | Smarca5 |
Synonyms : | SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; mSnf2h; sucrose nonfermenting protein 2 homolog; Snf2h; MommeD4; 4933427E24Rik; D030040M08Rik; D330027N15Rik |
Gene ID : | 93762 |
mRNA Refseq : | NM_053124 |
Protein Refseq : | NP_444354 |
UniProt ID : | Q91ZW3 |
Products Types
◆ Recombinant Protein | ||
SMARCA5-8462M | Recombinant Mouse SMARCA5 Protein, His (Fc)-Avi-tagged | +Inquiry |
SMARCA5-01H | Recombinant Human SMARCA5 Protein, FLAG/6His-tagged | +Inquiry |
SMARCA5-4152R | Recombinant Rhesus Macaque SMARCA5 Protein, His (Fc)-Avi-tagged | +Inquiry |
SMARCA5-2045H | Recombinant Human SMARCA5 Protein, His (Fc)-Avi-tagged | +Inquiry |
SMARCA5-15598M | Recombinant Mouse SMARCA5 Protein | +Inquiry |
◆ Lysates | ||
SMARCA5-1671HCL | Recombinant Human SMARCA5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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