Recombinant Mouse Sod2 Protein, His-tagged
Cat.No. : | Sod2-7342M |
Product Overview : | Recombinant mouse Sod2, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
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Description : | Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. |
Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Liquid |
Molecular Mass : | 24.6 kDa |
Protein length : | 25-222 |
AA Sequence : | MGSSHHHHHHSSGLVPRGSHMGSKH SLPDLPYDYGALEPHINAQIMQLHH SKHHAAYVNNLNATEEKYHEALAKG DVTTQVALQPALKFNGGGHINHTIF WTNLSPKGGGEPKGELLEAIKRDFG SFEKFKEKLTAVSVGVQGSGWGWLG FNKEQGRLQIAACSNQDPLQGTTGL IPLLGIDVWEHAYYLQYKNVRPDYL KAIWNVINWENVTERYTACKK |
Purity : | > 95 % by SDS-PAGE |
Stability : | Shelf life: one year from despatch. |
Storage : | Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing. |
Concentration : | 1.0 mg/mL (determined by bradford assay) |
Storage Buffer : | In Phosphate buffered saline (pH7.4) containing 10 % glycerol, 1 mM DTT. |
Gene Name : | Sod2 superoxide dismutase 2, mitochondrial [ Mus musculus (house mouse) ] |
Official Symbol : | Sod2 |
Synonyms : | Sod2; superoxide dismutase 2, mitochondrial; Mn; Sod; MnSOD; Sod-2; superoxide dismutase [Mn], mitochondrial; manganese SOD; manganese superoxide dismutase; EC 1.15.1.1 |
Gene ID : | 20656 |
mRNA Refseq : | NM_013671 |
Protein Refseq : | NP_038699 |
UniProt ID : | P09671 |
Products Types
◆ Recombinant Protein | ||
SOD2-2070H | Recombinant Human SOD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
SOD2-700C | Recombinant Cynomolgus Monkey SOD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
SOD2-2540H | Recombinant Human SOD2 protein(31-210 aa), C-His-tagged | +Inquiry |
SOD2-5326R | Recombinant Rat SOD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
SOD2-2541H | Recombinant Human SOD2 protein(25-222 aa), N-GST-tagged | +Inquiry |
◆ Lysates | ||
SOD2-1575HCL | Recombinant Human SOD2 293 Cell Lysate | +Inquiry |
SOD2-1574HCL | Recombinant Human SOD2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionCurrent research on SOD2 focuses on understanding its role in different disease contexts and identifying potential therapeutic targets. Investigations are underway to elucidate the molecular mechanisms underlying SOD2 regulation, its involvement in age-related diseases, and the development of novel strategies to enhance SOD2 activity for therapeutic purposes. Additionally, studies are exploring the interplay between SOD2 and other cellular processes, aiming to uncover new insights into its biological functions.
Several approaches have been explored to enhance SOD2 activity as a potential therapeutic strategy. These include the use of small molecule activators, such as resveratrol and melatonin, which can upregulate SOD2 expression and improve cellular antioxidant defense. Additionally, gene therapy approaches aiming to increase SOD2 levels or activity have shown promise in preclinical studies.
As cells age, the expression and activity of SOD2 decline, resulting in increased levels of reactive oxygen species (ROS) and oxidative damage. The accumulation of ROS can promote cellular senescence, a state of irreversible growth arrest. SOD2 plays a crucial role in mitigating ROS-mediated DNA damage and preserving cellular integrity, thus influencing the aging process.
The expression of SOD2 is regulated by various transcription factors, including nuclear factor erythroid 2-related factor 2 (NRF2) and forkhead box O3 (FOXO3). These transcription factors bind to the promoter region of the SOD2 gene and initiate its transcription. Additionally, post-translational modifications, such as acetylation and phosphorylation, can also modulate the activity and stability of SOD2.
Certain genetic variations or polymorphisms in the SOD2 gene have been associated with altered enzyme activity and increased susceptibility to certain diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. These polymorphisms can affect the antioxidant capacity of SOD2, leading to an imbalance between reactive oxygen species generation and scavenging, thereby contributing to disease pathogenesis.
SOD2, also known as mitochondrial superoxide dismutase, is an enzyme responsible for the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen within the mitochondria. This antioxidant activity helps to protect cells from oxidative stress and maintain redox homeostasis in the mitochondria.
SOD2 is known to interact with various proteins and signaling pathways to regulate cellular processes. For instance, SOD2 interacts with the nuclear factor kappa B (NF-κB) pathway, modulating its activity and downstream gene expression. SOD2 also interacts with other antioxidant enzymes, such as catalase and glutathione peroxidase, forming a coordinated antioxidant defense system within cells.
Customer Reviews (3)
Write a reviewIt has earned my trust with its outstanding stability and reproducibility.
After using this protein reagent, my protein gel electrophoresis results are notably clear, aiding in analysis and interpretation.
Engaging confidently in academic discussions and collaborations with peers is possible due to this reagent's exceptional performance.
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