Recombinant Mouse Spin1 Protein, Myc/DDK-tagged

• Cat.No.: Spin1-6094M
• Product Overview: Purified recombinant protein of mouse full-length spindlin 1 (Spin1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 30.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Spin1 spindlin 1 [ Mus musculus (house mouse) ]
• Official Symbol: Spin1
• Synonyms: Spin1; spindlin 1; Spin; spindlin-1; 30000 Mr metaphase complex; SSEC P; spindlin1
• Gene ID: 20729
• mRNA Refseq: NM_146043
• Protein Refseq: NP_666155
• UniProt ID: Q61142