Recombinant Mouse TIMP1 Protein, His-tagged

• Cat.No.: TIMP1-1034M
• Product Overview: Recombinant mouse TIMP1 protein, fused to His tag at C-terminus, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Mouse
• Tag: His
• Form: 20 mM Tris, 150 mM NaCl, pH 8.0
• Molecular Mass: 22 kDa
• Purity: Protein formulated and vialed at >50 ug/mL in specified buffer
• Concentration: Protein formulated and vialed at >50 ug/mL in specified buffer

Gene Information

• Gene Name: Timp1 tissue inhibitor of metalloproteinase 1 [ Mus musculus ]
• Official Symbol: TIMP1
• Synonyms: Clgi; EPA; Timp; TIMP-1; TPA-S1
• Gene ID: 21857
• mRNA Refseq: NM_001044384
• Protein Refseq: NP_035723

Reviews

04/16/2021

The efficient delivery of this product ensured that our research timelines were met without any complications.

08/03/2020

Impressed by the professionalism of the customer service team—responsive and knowledgeable about the entire product range.

12/08/2018

This recombined protein has become a go-to in our lab due to its reliability and the precision it brings to our experiments.

Q&As

What are the molecular consequences of dysregulated TIMP1 expression in cancer progression?

Dysregulated TIMP1 expression in cancer can disrupt the balance between MMPs and TIMPs, contributing to excessive extracellular matrix degradation, invasion, and metastasis.

Can you explain the molecular role of TIMP1 in the inhibition of metalloproteinases?

TIMP1 inhibits metalloproteinases by forming a complex with them, blocking their active sites and preventing the degradation of extracellular matrix components.

How does the nuclear localization of FXN contribute to its role in cellular processes?

FXN's nuclear localization is associated with its involvement in DNA repair processes, influencing genomic stability and contributing to the overall cellular response to stress.

Can you explain the interplay between TIMP1 and the immune system in inflammatory processes?

TIMP1 has immunomodulatory effects, influencing inflammation by regulating immune cell migration, cytokine production, and interactions with the extracellular matrix.

What is the significance of TIMP1 in tissue homeostasis and repair?

TIMP1 plays a crucial role in tissue homeostasis and repair by controlling the activity of MMPs, which are involved in remodeling the extracellular matrix during physiological and pathological processes.