Recombinant Mouse Tumor Necrosis Factor (Ligand) Superfamily, Member 11
Cat.No. : | Tnfsf11-116M |
Product Overview : | Recombinant Mouse sRANKL produced in E.coli is single, non-glycosylated, polypeptide chain containing 179 amino acids and having a total molecular mass of 20 kDa. CD254 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | Tnfsf11-116M |
Description : | RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. |
Source : | Escherichia Coli. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Purity : | Greater than 95.0% as determined by: a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Formulation : | The protein (1mg/ml) was lyophilized with 10mM NaP, pH 7.5+ 50 NaCl. |
Solubility : | It is recommended to reconstitute the lyophilized sRANKL in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Amino acid sequence : | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Phe-Ser-Gly-Ala. |
Biological Activity : | Measured by its ability to induce osteoclast formation on murine RAW264.7 cells using a concentration of 5.0-10.0 ng/ml. |
Storage : | Lyophilized TNFSF11 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution sRANKL should be stored at 4°Cbetween 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. |
Gene Name : | Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 [ Mus musculus ] |
Synonyms : | Tnfsf11; tumor necrosis factor (ligand) superfamily, member 11; ODF; OPG; OPGL; RANKL; Ly109l; Trance; OPG ligand; osteoprotegerin ligand; osteoclast differentiation factor; receptor activator of NF-kappaB ligand; tumor necrosis factor-related activation-induced cytokine; Ly109l |
Gene ID : | 21943 |
mRNA Refseq : | NM_011613 |
Protein Refseq : | NP_035743 |
UniProt ID : | O35235 |
Chromosome Location : | 14 D3; 14 45.0 cM |
Pathway : | Cytokine-cytokine receptor interaction |
Function : | cytokine activity; protein binding; receptor activity; tumor necrosis factor receptor binding |
Products Types
◆ Recombinant Protein | ||
TNFSF11-2024M | Recombinant Mouse TNFSF11 Protein | +Inquiry |
TNFSF11-2022H | Recombinant Human TNFSF11 Protein, MYC/DDK-tagged | +Inquiry |
Tnfsf11-85M | Active Recombinant Mouse Tnfsf11 Protein (Pro143-Asp316), C-His tagged, Animal-free, Carrier-free | +Inquiry |
TNFSF11-683M | Recombinant Mouse TNFSF11 Protein | +Inquiry |
TNFSF11-459H | Recombinant Human TNFSF11 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
TNFSF11-998HCL | Recombinant Human TNFSF11 cell lysate | +Inquiry |
TNFSF11-1093HCL | Recombinant Human TNFSF11 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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