Recombinant Mouse Tyro3 Protein, Myc/DDK-tagged

• Cat.No.: Tyro3-6758M
• Product Overview: Purified recombinant protein of mouse full-length TYRO3 protein tyrosine kinase 3 (cDNA clone MGC:90668 IMAGE:30356080), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 145.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tyro3 TYRO3 protein tyrosine kinase 3 [ Mus musculus (house mouse) ]
• Official Symbol: Tyro3
• Synonyms: Tyro3; TYRO3 protein tyrosine kinase 3; R; Br; Sk; Ti; Brt; Dtk; Rse; Sky; Tif; Etk-2; TK19-2; tk19-1; AI323366; etk2/tyro3; tyrosine-protein kinase receptor TYRO3; receptor tyrosine kinase; tyrosine-protein kinase DTK; tyrosine-protein kinase RSE; tyrosine-protein kinase TIF; EC 2.7.10.1
• Gene ID: 22174
• mRNA Refseq: NM_019392
• Protein Refseq: NP_062265
• UniProt ID: P55144