Recombinant Mouse Wwox Protein, Myc/DDK-tagged

• Cat.No.: Wwox-7014M
• Product Overview: Purified recombinant protein of Mouse WW domain-containing oxidoreductase (Wwox), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 46.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Wwox WW domain-containing oxidoreductase [ Mus musculus (house mouse) ]
• Official Symbol: Wwox
• Synonyms: WWOX; WW domain-containing oxidoreductase; WW-domain oxidoreductase; WOX1; 5330426P09Rik; 9030416C10Rik
• Gene ID: 80707
• mRNA Refseq: NM_019573
• Protein Refseq: NP_062519
• UniProt ID: Q91WL8