Recombinant Mouse Zfyve19 Protein, Myc/DDK-tagged

• Cat.No.: Zfyve19-7102M
• Product Overview: Purified recombinant protein of Mouse zinc finger, FYVE domain containing 19 (Zfyve19), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 43.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Zfyve19 zinc finger, FYVE domain containing 19 [ Mus musculus (house mouse) ]
• Official Symbol: Zfyve19
• Synonyms: ZFYVE19; zinc finger, FYVE domain containing 19; zinc finger FYVE domain-containing protein 19; 1500041L05Rik; MGC117612
• Gene ID: 72008
• mRNA Refseq: NM_028054
• Protein Refseq: NP_082330
• UniProt ID: Q9DAZ9