Recombinant ProMatrix Metalloproteinase-7
Cat.No. : | MMP7-94 |
Product Overview : | Matrix metalloproteinase-7 (MMP-7) also known as matrilysin and PUMP (EC 3.4.24.23) cleaves a number of substrates including collagen types IV and X, elastin, fibronectin, gelatin, laminin and proteoglycans. MMP-7 is closely related to the stromelysin family members but is encoded by a different gene. MMP-7 is the smallest of all the MMPs consisting of a pro-peptide domain and a catalytic domain. It lacks the hemopexin-like domain common to other members of the MMPs. MMP-7 is secreted as a 28 kDa proenzyme and can be activated in vitro by organomercurials and trypsin and in vivo by MMP-3 to a 18 kDa active MMP-7 enzyme. Once activated, MMP-7 can activate pro-MMP-1 and pro-MMP-9 but not pro-MMP-2. MMP-7 is widely expressed having been reported in elevated levels in cycling endometrium as well as in colorectal cancers and adenomas, hepatocellular carcinomas, rectal carcinomas, and approximately 50% of gliomas. |
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- Gene Information
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Cat. No. : | MMP7-94 |
Source : | Escherichia Coli. |
Physical Appearance : | Sterile clear liquid solution. |
Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Formulation : | The protein (1 mg/ml) contains the following additives 25 mM Tris-HCl (pH 7.5), 150 mM NaCl, 5 mM CaCl2, 0.01% Brij-35 and 0.02% NaN3. |
Biological Activity : | The specific activity was found to be 1400 IU/mg. |
Unit Definition : | One unit is defined as the digestion of 1 µg Azocoll/min at 37°C. |
Stability : | ProMMP-7 although stable at 4°C for 3 weeks, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. |
Synonyms : | Matrilysin; EC 3.4.24.23; MMP-7; MMP7; Matrin; MPSL1; PUMP-1; PUMP1; matrin; Pump-1 protease; Uterine metalloproteinase; Matrix metalloproteinase-7; matrix metallopeptidase 7 (matrilysin, uterine); matrix metalloproteinase 7; matrix metalloproteinase 7 (matrilysin, uterine); uterine matrilysin; matrilysin, matrin; uterine metalloendopeptidase; putative (or punctuated) metalloproteinase-1; matrix metalloproteinase pump 1; MMP 7; PUMP-1 proteinase; PUMP; metalloproteinase pump-1; putative metalloproteinase; MMP. |
Synonyms : | Matrilysin; EC 3.4.24.23; MMP-7; MMP7; Matrin; MPSL1; PUMP-1; PUMP1; matrin; Pump-1 protease; Uterine metalloproteinase; Matrix metalloproteinase-7; matrix metallopeptidase 7 (matrilysin, uterine); matrix metalloproteinase 7; matrix metalloproteinase 7 (matrilysin, uterine); uterine matrilysin; matrilysin, matrin; uterine metalloendopeptidase; putative (or punctuated) metalloproteinase-1; matrix metalloproteinase pump 1; MMP 7; PUMP-1 proteinase; PUMP; metalloproteinase pump-1; putative metalloproteinase; MMP. |
Products Types
◆ Recombinant Protein | ||
MMP7-3374R | Recombinant Rat MMP7 Protein, His (Fc)-Avi-tagged | +Inquiry |
MMP7-2612H | Recombinant Human MMP7 protein(18-267 aa), N-SUMO & C-His-tagged | +Inquiry |
MMP7-1125C | Recombinant Chicken MMP7 Protein, His&GST-tagged | +Inquiry |
MMP7-001H | Recombinant Human MMP7 Protein, His-tagged | +Inquiry |
Mmp7-10595M | Recombinant Mouse Mmp7 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
MMP7-28205TH | Native Human MMP7 | +Inquiry |
◆ Lysates | ||
MMP7-2883HCL | Recombinant Human MMP7 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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