Recombinant Rat AGTRAP Protein Pre-coupled Magnetic Beads

• Cat.No.: AGTRAP-224R-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Rat
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Agtrap angiotensin II receptor-associated protein [ Rattus norvegicus ]
• Official Symbol: AGTRAP
• Gene ID: 298646
• mRNA Refseq: NM_001007654.1
• Protein Refseq: NP_001007655.1
• UniProt ID: Q642A2

Reviews

01/05/2022

It was delivered quickly, and the product was of exceptional quality, meeting all my research needs.

12/19/2021

Outstanding products. Impressive results!

08/27/2020

The protein I purchased was a game-changer for my experiments. Its high activity and purity significantly improved the reliability of my findings

04/10/2019

Reliable and high-quality protein. Recommended!

07/03/2018

I've been using proteins for years, and this one ranks among the best.

Q&As

Is AGTRAP involved in the pathophysiology of cardiovascular diseases?

Yes, dysregulation of AGTRAP expression or function has been implicated in various cardiovascular conditions, including hypertension, cardiac hypertrophy, and heart failure.

Can AGTRAP affect AGTR1 expression levels?

Yes, AGTRAP can regulate AGTR1 expression by influencing its trafficking and degradation, thus impacting the overall abundance of AGTR1 receptors.

How does AGTRAP influence AGTR1-mediated intracellular signaling?

AGTRAP can modulate AGTR1 signaling by affecting the receptor's coupling to downstream signaling pathways, including G proteins and β-arrestins.

Where is AGTRAP primarily expressed in the human body?

AGTRAP is widely expressed in various tissues, including the heart, kidney, liver, and brain.

What is the role of AGTRAP in blood pressure regulation?

AGTRAP acts as a negative regulator of AGTR1, thereby modulating the effects of angiotensin II on blood pressure control and vascular function.

What is the subcellular localization of AGTRAP?

AGTRAP is primarily localized in the endoplasmic reticulum (ER) and Golgi apparatus, where it interacts with AGTR1 during receptor maturation and trafficking.

How does AGTRAP interact with AGTR1?

AGTRAP physically associates with AGTR1 and modulates its activity by influencing receptor trafficking, signaling, and desensitization.

Are there any AGTRAP-related diseases or disorders?

While the precise involvement of AGTRAP in specific diseases is still being elucidated, dysregulation of AGTRAP has been associated with cardiovascular diseases, hypertension, and altered response to angiotensin II.

Are there any known AGTRAP-binding partners?

AGTRAP has been reported to interact with several proteins involved in receptor trafficking, including G protein-coupled receptor-associated sorting proteins (GASP), which influence AGTR1 cell surface expression.

What techniques are commonly used to study AGTRAP function?

Techniques such as immunoprecipitation, co-immunoprecipitation, fluorescence microscopy, and genetic manipulation in cellular and animal models are employed to investigate AGTRAP's role and molecular mechanisms.