Recombinant Rat ALDOA Protein

• Cat.No.: ALDOA-625R
• Product Overview: Recombinant Rat ALDOA full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Rat
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Aldoa aldolase A, fructose-bisphosphate [ Rattus norvegicus ]
• Official Symbol: ALDOA
• Gene ID: 24189
• mRNA Refseq: NM_001177305.1
• Protein Refseq: NP_001170776.1
• UniProt ID: P05065

Reviews

08/10/2021

In addition to its remarkable quality and exceptional technical support, the ALDOA Protein boasts an impressive range of applications.

08/20/2020

Its remarkable quality, versatility, and the manufacturer's commitment to customer satisfaction make it the perfect choice for researchers seeking a premier protein that will undoubtedly enhance their experimental endeavors.

07/24/2019

The ALDOA Protein has exceeded my expectations by consistently delivering outstanding results and providing exceptional technical support.

Q&As

How is ALDOA protein regulated in the body?

ALDOA protein expression can be regulated by various factors. For example, hypoxia, low oxygen levels, can induce the upregulation of ALDOA expression. Additionally, certain transcription factors and signaling pathways can influence ALDOA expression, although the full regulatory mechanisms are still being investigated.

Are there any known genetic mutations or polymorphisms associated with ALDOA protein?

Yes, mutations in the ALDOA gene have been reported in rare cases of hereditary fructose intolerance. These mutations impair the function of ALDOA, leading to metabolic disturbances upon fructose consumption.

What are the consequences of ALDOA protein deficiency?

Complete deficiency of ALDOA protein is not compatible with life, as it is required for normal glycolytic function in cells. However, mutations in the ALDOA gene that partially impair its function can result in hereditary fructose intolerance, an autosomal recessive disorder characterized by the inability to metabolize fructose.

Are there any known inhibitors or activators of ALDOA protein?

Several compounds have been identified as potential inhibitors of ALDOA activity, including small molecules and natural compounds. However, their efficacy and specificity for ALDOA inhibition are still being studied. Currently, there are no known activators of ALDOA protein.

Are there any known interactions of ALDOA protein with other molecules or proteins?

ALDOA protein has been found to interact with various molecules and proteins involved in glycolysis and other metabolic pathways. It has also been reported to interact with cytoskeletal proteins and actin, suggesting potential roles in cellular structure and motility.

Is ALDOA protein involved in any other biological processes apart from glycolysis?

Yes, ALDOA protein has been implicated in other biological processes besides glycolysis. It has been shown to play a role in cell proliferation, differentiation, and apoptosis. ALDOA has also been associated with the formation and maintenance of neuronal networks in the brain.

Can ALDOA protein be used as a diagnostic marker for any diseases?

High expression of ALDOA protein has been observed in certain types of cancers, such as lung, breast, and ovarian cancer. It has been proposed as a potential biomarker for these cancers, although further research is needed to validate its clinical utility.

Can ALDOA protein be used as a prognostic marker for any diseases?

There is some evidence to suggest that ALDOA protein expression levels may have prognostic value in certain types of cancer. Higher expression of ALDOA has been correlated with poorer prognosis and reduced survival rates in some studies. However, more research is needed to establish its utility as a reliable prognostic marker.

Can ALDOA protein be targeted for cancer therapy?

There is emerging evidence suggesting that ALDOA protein may be a potential target for cancer therapy. ALDOA overexpression has been observed in various cancers and is associated with tumor growth, metastasis, and resistance to therapy. Inhibition of ALDOA has been shown to have anti-tumor effects in preclinical studies, making it a promising target for cancer therapy.

Does ALDOA protein have any isoforms or alternative splicing variants?

Yes, ALDOA protein has two known isoforms, ALDOA-1 and ALDOA-2, which are generated by alternative splicing of the ALDOA gene. ALDOA-1 is the major isoform expressed in most tissues, while ALDOA-2 is predominantly found in the brain.

Is ALDOA protein associated with any neurological disorders?

Some studies have suggested a potential role of ALDOA protein in neurological disorders. ALDOA expression has been found to be dysregulated in certain neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. However, the exact mechanisms by which ALDOA contributes to these disorders are still unclear and require further investigation.

Are there any known post-translational modifications of ALDOA protein?

Yes, ALDOA protein is known to undergo post-translational modifications, such as phosphorylation and acetylation. Phosphorylation of ALDOA has been shown to regulate its enzyme activity, subcellular localization, and protein-protein interactions. Acetylation of ALDOA has also been implicated in the regulation of its enzymatic activity.

Can ALDOA protein be used as a biomarker for any diseases?

ALDOA protein has been proposed as a biomarker for certain diseases. Increased ALDOA expression has been observed in various cancers, and its levels have been correlated with tumor aggressiveness and poor prognosis. Additionally, ALDOA has been suggested as a potential biomarker for myocardial infarction and acute kidney injury. However, more research is needed to validate ALDOA as a reliable biomarker in clinical settings.

Can ALDOA protein be used as a drug target for metabolic disorders?

Targeting ALDOA protein for the treatment of metabolic disorders is still in the early stages of research. While its involvement in glycolysis suggests it may be a potential target, further studies are needed to evaluate its feasibility and safety as a drug target.

Can ALDOA protein be targeted for therapeutic purposes?

While it is primarily known for its role in glycolysis, ALDOA protein has emerged as a potential target for cancer therapy. Inhibiting ALDOA activity has been explored as a strategy to selectively kill cancer cells or sensitize them to other anticancer treatments. However, more research is needed to develop effective and safe ALDOA-targeted therapies.

Are there any known genetic polymorphisms in the ALDOA gene associated with disease susceptibility?

Although rare, there have been reports of genetic polymorphisms in the ALDOA gene associated with increased susceptibility to certain diseases, such as ischemic stroke and coronary artery disease. However, the functional implications of these polymorphisms need further investigation.

Are there any known interactions between ALDOA protein and other cellular pathways?

ALDOA protein has been shown to interact with various cellular pathways and proteins. For example, it has been found to interact with heat shock proteins, cytoskeletal proteins, and enzymes involved in glucose metabolism. These interactions suggest potential crosstalk between ALDOA and other cellular processes.