Recombinant Rat AMIGO1 Protein Pre-coupled Magnetic Beads

• Cat.No.: AMIGO1-308R-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Rat
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Amigo1 adhesion molecule with Ig like domain 1 [ Rattus norvegicus ]
• Official Symbol: AMIGO1
• Gene ID: 295365
• mRNA Refseq: NM_206881.1
• Protein Refseq: NP_996764.1
• UniProt ID: Q80ZD7

Reviews

11/12/2022

Sensitivity in detecting low-abundance proteins.

08/14/2022

Specific target detection in various tissue types.

04/23/2022

Robust assay performance in high-throughput screening.

Q&As

What is the role of AMIGO1 in neurite outgrowth and axon guidance?

AMIGO1 plays a critical role in promoting neurite outgrowth and axon guidance by regulating cytoskeletal dynamics and signaling pathways involved in axonal growth cone guidance.

What are the molecular mechanisms underlying the interaction between AMIGO1 and its binding partners?

AMIGO1 interacts with various binding partners, including cell adhesion molecules and ion channels, through both homophilic and heterophilic interactions, contributing to neuronal cell-cell communication and synaptic connectivity.

How does AMIGO1 localization change during neuronal development and maturation?

During neuronal development, AMIGO1 undergoes dynamic changes in its subcellular localization, transitioning from a primarily intracellular distribution to a more plasma membrane-associated localization.

Can AMIGO1 regulate neuronal migration during brain development?

AMIGO1 has been implicated in the regulation of neuronal migration during brain development, particularly in the formation of cortical layers and the establishment of neuronal circuitry.

How does AMIGO1 influence neuronal survival and apoptosis?

AMIGO1 exerts a neuroprotective effect by promoting neuronal survival and inhibiting apoptosis through the activation of intracellular signaling pathways that regulate cell survival and anti-apoptotic factors.

What is the impact of AMIGO1 on myelination and oligodendrocyte development?

AMIGO1 is involved in myelination processes and oligodendrocyte development, promoting the differentiation and maturation of oligodendrocytes and facilitating proper myelin sheath formation.

What is the tissue-specific expression pattern of AMIGO1 in different organs?

AMIGO1 shows a distinct tissue-specific expression pattern, with high expression in the brain, particularly in the developing and mature neurons, as well as in other organs such as the heart, kidney, and lung.

Does AMIGO1 modulate synaptic plasticity and neurotransmission?

AMIGO1 has been shown to modulate synaptic plasticity by regulating the surface expression of neurotransmitter receptors and modulating synaptic strength and connectivity.

Is there a correlation between AMIGO1 expression and neurological disorders?

Altered expression or dysregulation of AMIGO1 has been associated with various neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorders, suggesting its potential involvement in disease pathogenesis.

Can modulation of AMIGO1 expression or activity be a potential therapeutic approach for neurological conditions?

Modulation of AMIGO1 expression or activity represents a potential therapeutic target for neurological conditions, and further studies investigating the specific mechanisms and downstream signaling pathways regulated by AMIGO1 may unveil novel therapeutic strategies for these disorders.