Recombinant Rat ARL13A Protein Pre-coupled Magnetic Beads

• Cat.No.: ARL13A-434R-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Rat
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Arl13a ADP-ribosylation factor-like 13A [ Rattus norvegicus ]
• Official Symbol: ARL13A
• Gene ID: 501617
• mRNA Refseq: NM_001024366.1
• Protein Refseq: NP_001019537.1
• UniProt ID: Q6AXT3

Reviews

12/30/2022

By choosing the ARL13A protein and partnering with the manufacturer, researchers can confidently conduct their trials, achieve reliable results, and contribute to groundbreaking discoveries.

06/28/2022

Whether it is protein-protein interactions, enzymatic assays, or cellular studies, ARL13A protein delivers consistent and accurate data, making it a valuable tool for researchers.

01/04/2022

Its purity and integrity ensure reliable and reproducible results in a wide range of applications.

09/04/2021

The ARL13A protein offers several advantageous features that make it an ideal choice for researchers conducting trials.

04/21/2020

ARL13A protein is of exceptional quality and is highly recommended for meeting experimental needs.

10/13/2019

Its ability to accurately detect proteins and visualize their structures offers a valuable toolkit for advancing scientific understanding and discoveries.

08/17/2019

The manufacturer of the ARL13A protein plays a crucial role in supporting researchers during their trials.

09/11/2018

the protein's high quality ensures accurate and reliable results, enabling precise analysis and interpretation of experimental data.

07/24/2018

the ARL13A protein demonstrates exceptional stability, allowing for prolonged storage and usage without compromising its integrity.

06/26/2018

The outstanding performance of ARL13A protein in both ELISA and protein electron microscopy structure analysis positions it as a highly valuable asset in diverse research areas.

Q&As

Can ARL13A be targeted for therapeutic interventions?

Targeting ARL13A directly for therapeutic interventions is currently challenging due to its essential role in ciliary function. However, understanding the precise mechanisms by which ARL13A is involved in ciliopathies may provide insights into developing therapies that modulate ciliary signaling or compensatory mechanisms to mitigate disease symptoms.

Is there any association between ARL13A and cancer?

Although ARL13A is primarily associated with ciliopathies, abnormal ciliary function has been implicated in various types of cancer. Some studies have found alterations in ARL13A expression or localization in certain cancer cells, suggesting potential involvement in cancer development and progression. However, more research is needed to fully elucidate its role in cancer biology.

Does ARL13A have any known interacting partners?

ARL13A interacts with various proteins involved in ciliary trafficking and signaling. For example, it interacts with intraflagellar transport (IFT) proteins, which are crucial for transporting proteins within cilia. Other interactors include proteins involved in vesicular trafficking and membrane remodeling within the ciliary compartment.

How does ARL13A contribute to ciliary function?

ARL13A is involved in regulating the structure and function of the ciliary membrane. It interacts with other ciliary proteins and is required for proper trafficking and localization of membrane proteins within the cilium. These processes are crucial for correct ciliary signaling and function.

Can ARL13A interact with other signaling pathways?

Yes, ARL13A can interact with other signaling pathways within the cell. For instance, it has been shown to interact with the Hedgehog signaling pathway, which regulates development and patterning in various tissues. ARL13A helps localize and regulate the trafficking of key components involved in Hedgehog signaling within the cilia.

Does ARL13A play a role in embryonic development?

Yes, ARL13A is crucial for embryonic development due to its involvement in cilia formation. Cilia are essential for various signaling pathways that regulate cellular differentiation, tissue patterning, and organ development during embryogenesis.

Can ARL13A mutations cause ciliopathies?

Yes, mutations in the ARL13A gene have been associated with various ciliopathies, which are a group of genetic disorders characterized by abnormal cilia structure or function. These disorders can affect multiple organs and systems, leading to a wide range of clinical manifestations.

Is ARL13A found exclusively in cilia?

While ARL13A is predominantly localized to primary cilia, it has also been found in other cellular compartments such as the Golgi apparatus and the endosomal system. These additional locations suggest potential roles for ARL13A in other cellular processes beyond ciliogenesis.

Can ARL13A be used as a biomarker for ciliopathies?

ARL13A is not commonly used as a specific biomarker for ciliopathies. However, its abnormal expression or localization patterns in patient samples may provide insight into ciliary dysfunction, supporting the diagnosis of certain ciliopathies in conjunction with other clinical and genetic analyses.

Are there any pharmacological approaches to target ARL13A?

Currently, there are no specific pharmacological agents that directly target ARL13A. However, research is being conducted on various compounds that modulate cilia-related processes and may indirectly affect ARL13A function. These compounds could potentially be utilized to treat ciliopathy-associated disorders in the future.

Does ARL13A have any paralogs or closely related proteins?

Yes, ARL13A belongs to the ARL13 subfamily of ADP-ribosylation factors (ARLs), which includes ARL13B. ARL13B shares a high degree of sequence similarity with ARL13A and is also involved in ciliary functions. Both proteins are essential for ciliogenesis and play overlapping roles in vertebrate development.

Are there any known diseases associated with ARL13A mutations?

Yes, mutations in the ARL13A gene have been linked to a range of ciliopathies that affect multiple organ systems. These disorders can include neurological abnormalities, renal cysts, retinal degeneration, and skeletal abnormalities, among others.

Are there any animal models for studying ARL13A-related ciliopathies?

Yes, several animal models, including mice and zebrafish, with ARL13A mutations or knockdown have been developed to study ciliopathies associated with ARL13A dysfunction. These models help in understanding the biological mechanisms underlying these disorders and potential therapeutic interventions.

What are some ciliopathies associated with ARL13A mutations?

Some ciliopathies associated with ARL13A mutations include Joubert syndrome, Bardet-Biedl syndrome, Meckel syndrome, and oral-facial-digital syndrome type V. These disorders often involve abnormalities in the development and function of multiple organs due to impaired ciliary signaling.