Recombinant Rat Arpc1b, His-tagged
Cat.No. : | Arpc1b-3103R |
Product Overview : | Actin-related protein 2/3 complex subunit 1B (Arpc1b) |
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Source : | E. Coli or Yeast |
Species : | Rat |
Tag : | His |
Form : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Protein length : | 372 |
Purity : | >90% |
Notes : | Small volumes of Arpc1b recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Store at -20 degree C. For extended storage, store at -20 or -80 degree C. |
Storage Buffer : | PBS pH 7.4, 50% glycerol |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | Arpc1b actin related protein 2/3 complex, subunit 1B [ Rattus norvegicus ] |
Official Symbol : | Arpc1b |
Synonyms : | ARPC1B; actin related protein 2/3 complex, subunit 1B; actin-related protein 2/3 complex subunit 1B; p41-ARC; arp2/3 complex 41 kDa subunit; Actin-related protein complex 1b; |
Gene ID : | 54227 |
mRNA Refseq : | NM_019289 |
Protein Refseq : | NP_062162 |
Pathway : | B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem |
Function : | actin binding; |
Products Types
◆ Recombinant Protein | ||
ARPC1B-454R | Recombinant Rat ARPC1B Protein, His (Fc)-Avi-tagged | +Inquiry |
ARPC1B-748M | Recombinant Mouse ARPC1B Protein, His (Fc)-Avi-tagged | +Inquiry |
ARPC1B-380H | Recombinant Human ARPC1B Protein, His (Fc)-Avi-tagged | +Inquiry |
ARPC1B-2339C | Recombinant Chicken ARPC1B | +Inquiry |
ARPC1B-845H | Recombinant Human ARPC1B protein, GST-tagged | +Inquiry |
◆ Lysates | ||
ARPC1B-8686HCL | Recombinant Human ARPC1B 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionDysregulation of the ARPC1B protein has been implicated in various types of cancer, including breast cancer and colorectal cancer. Additionally, mutations or deletions in the ARPC1B gene have been linked to developmental disorders such as intellectual disability and abnormal brain development.
The ARPC1B protein is involved in cancer progression by promoting cell motility, invasion, and metastasis. It functions within the Arp2/3 complex to facilitate the formation of actin-based protrusions that allow cancer cells to move and invade surrounding tissues.
Modulation of the ARPC1B protein or its associated Arp2/3 complex could be a potential therapeutic approach for diseases involving aberrant actin cytoskeleton dynamics or cellular motility. However, further research is necessary to fully understand the functional consequences of ARPC1B dysregulation and to develop targeted therapeutic strategies.
Currently, there are no specific inhibitors targeting the ARPC1B protein available for therapeutic use. However, as the Arp2/3 complex is an essential component of actin cytoskeleton regulation, inhibitors targeting the interaction between the complex and its activators may hold potential as anti-cancer agents.
ARPC1B is expressed in the developing brain and is crucial for proper neuronal migration and cortical development. Mutations or deletions in the ARPC1B gene have been associated with intellectual disability and cortical malformations, which are thought to result from disrupted actin dynamics impairing the normal development and function of neural circuits.
Currently, there are no specific drugs or therapeutic interventions targeting ARPC1B. However, as ARPC1B is involved in actin dynamics and cell migration, targeting other components of the actin cytoskeleton or signaling pathways that regulate actin polymerization may indirectly impact ARPC1B function and could be explored as potential therapeutic strategies.
Customer Reviews (3)
Write a reviewTheir team of experts is highly knowledgeable, responsive, and dedicated to providing prompt solutions to any challenges I may face.
By harnessing the power of the ARPC1B protein, I can harness its outstanding quality and tap into its potential to obtain dependable and meaningful findings.
The ARPC1B protein is undoubtedly a superior choice, boasting extraordinary quality that guarantees it will fulfill all my experimental requirements.
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