Recombinant Rat ART2 Protein, His (Fc)-Avi-tagged

• Cat.No.: ART2-465R
• Product Overview: Recombinant Rat ART2 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Rat
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Art2 ADP-ribosyltransferase 2 [ Rattus norvegicus ]
• Official Symbol: ART2
• Gene ID: 293152
• mRNA Refseq: NM_198735.2
• Protein Refseq: NP_942030.1
• UniProt ID: P20974

Reviews

06/20/2022

One notable advantage of the ART2 protein is the outstanding technical support provided by the manufacturer.

03/23/2022

Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.

12/27/2021

Their expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.

Q&As

How is ART2 expression regulated in normal physiological conditions?

The precise regulation of ART2 gene expression is not well understood, but it may be influenced by various transcription factors and cellular signaling pathways.

How does ART2 catalyze ADP-ribosylation?

ART2 transfers ADP-ribose from NAD+ to specific arginine residues on substrate proteins, modifying their structure and function.

Does ART2 have any non-enzymatic functions or interactions with other proteins?

Aside from its enzymatic role in ADP-ribosylation, ART2 does not have any known non-enzymatic functions or specific protein interactions.

Are there any therapeutic applications targeting ART2?

Currently, there are no specific therapeutics targeting ART2 for direct modulation. However, research on ADP-ribosylation and its associated pathways may have therapeutic implications in the future.

In which tissues or organs is ART2 primarily expressed?

ART2 is predominantly expressed in the testes, adipose tissue, and certain immune cells like T cells and mast cells.

What are some known substrates of ART2?

ART2 primarily ADP-ribosylates arginine residues on various proteins including P2X purinergic receptors and certain immune cell markers such as CD4 and CD8.

Does ART2 activity change under pathological conditions?

The dysregulation of ADP-ribosylation, including ART2 activity, has been implicated in various diseases, such as cancer and inflammatory disorders. However, the specific role of ART2 in these conditions requires further investigation.

Is the activity of ART2 influenced by any cofactors or regulators?

ART2 activity is dependent on the presence of NAD+ as a substrate, and it can also be influenced by extracellular ATP levels and extracellular calcium.

Are there any known diseases or disorders associated with mutations in the ART2 gene?

Mutations in the ART2 gene have not been directly linked to specific diseases or disorders in humans so far.

Are there any known animal models or experimental systems used to study ART2 functions?

Animal models, such as ART2 knockout mice, have been generated to investigate the role of ART2 in vivo, providing insights into its physiological functions.