Recombinant Rat Resistin, FLAG-tagged

• Cat.No.: Retn-198R
• Product Overview: Recombinant rat resistin encoding the mature peptide (aa 19~114) of resistin was tagged with a FLAG peptide at the N-terminus. The tagged protein was expressed in a human embryonic kidney cell line,HEK293,and purified from conditioned media.

Specification

• Cat. No.: Retn-198R
• Description: Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins (monomeric peptide contains 11 cysteine residues) referred to as the RELM family, and is also described as ADSF (Adipose Tissue-Specific Secretory Factor) or FIZZ3 (Found in Inflammatory Zone 3). Mouse resistin is expressed as a 114 amino acid prepeptide; its hydrofobic Nterminal 20 amino acid signal peptide is cleaved before its secretion. Mouse resistin circulates in blood as a homodimeric protein consisting of two 94 amino acid polypeptides, which are disulfide-linked via Cys26. Resistin may be an important link between obesity and insulin resistance.
• Source: HEK293.
• Formulation: 0.2 m filtered solution in phosphate buffered saline, pH 7.2.
• Purity: >95%, as determined by SDS-PAGE.
• Endotoxin Level: <0.1EU/g, as determined by the LAL method.
• Stability Storage And Handling: Centrifuge the vial before opening to recover entire contents of the vial. Due to possible sublimation during storage, the buffer volume may decrease over time, however, the product is sold by mass and the amount of protein will remain constant.

Gene Information

• Gene Name: Retn resistin [ Rattus norvegicus ]
• Synonyms: Retn; resistin
• Gene ID: 246250
• mRNA Refseq: NM_144741
• Protein Refseq: NP_653342
• Chromosome Location: 12p12
• Function: hormone activity

Reviews

06/22/2020

Catalytic activity of RETN is excellent, no matter what the environment can maintain stable catalytic performance, its reliability is reliable.

05/27/2020

The quality of RETN they produce is guaranteed, and we can buy it with confidence.

05/22/2019

The stability of RETN is too strong to ignore, and it remains admirably stable after long storage.

Q&As

How does the expression level of RETN correlate with insulin resistance?

Expression level of RETN is associated with the development of insulin resistance. High levels of RETN can reduce insulin sensitivity, leading to decreased glycemic control, which promotes the development of insulin resistance.

What is the role of RETN in the treatment of diabetes and cardiovascular disease?

Studies have shown that regulating the expression level of RETN can influence the development and treatment effect of diabetes and cardiovascular disease. For example, certain drugs can improve insulin sensitivity and control blood sugar levels by inhibiting the expression level of RETN.

How can the expression level of RETN be used for the prediction and diagnosis of diabetes and cardiovascular disease?

Diabetes and cardiovascular disease can be predicted and diagnosed by measuring the expression level of RETN. For example, high levels of RETN may indicate a higher risk of disease and more severe disease conditions.

How to use mutation or abnormal expression of RETN for disease diagnosis and prognosis assessment?

Mutations and expression levels of the RETN gene can be detected to aid in diagnosing disease and assessing prognosis. For example, certain mutations may predict a higher risk and a worse prognosis.

What diseases are mutations or abnormal expression of RETN associated with?

Mutations or abnormal expression of RETN may be associated with a variety of diseases. For example, certain mutations can lead to abnormally elevated levels of their expression, increasing the risk of diabetes, cardiovascular disease, etc.

How does RETN relate to other biomarkers?

RETN has some association with other biomarkers. For example, in obesity and cardiovascular disease, the expression level of RETN can be used to assess the prognosis and therapeutic effect of the disease together with biomarkers such as adiponectin and leptin.