Recombinant Rat Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1

• Cat.No.: Serpine1-5516R
• Product Overview: Recombinant RatSerpine1 typically contains 95% active PAI-1.

Specification

• Cat. No.: Serpine1-5516R
• Description: Serpine1 is a serineprotease inhibitor (serpin) that functions as the principal inhibitor oftissue plasminogen activator (tPA) and urokinase (uPA), the activators ofplasminogen and hence fibrinolysis (the physiological breakdown of bloodclots). It is a serine protease inhibitor (serpin) protein (Serpine1). Theother PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by theplacenta and only present in significant amounts during pregnancy. Inaddition, protease nexin acts as an inhibitor of tPA and urokinase. Serpine1,however, is the main inhibitor of the plasminogen activators.
• Source: E. coli
• Species: Rat
• Form: Liquid in 0.05 Msodium acetate + 0.4 M NaCl + 1 mM EDTA, pH 5.0.
• Molecular Weight: 43.0 kDa
• Storage: Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: Serpine1
• Pathways: Adipogenesis; BloodClotting Cascade; Chagas disease (American trypanosomiasis); Complement andCoagulation Cascades; Dissolution of Fibrin Clot; Hemostasis; Plateletactivation; Platelet degranulation; Response to elevated platelet cytosolicCa2+; Senescence and Autophagy; TGF Beta Signaling Pathway; p53 pathway; p53signaling pathway

Gene Information

• Gene Name: Serpine1 serpin peptidaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1[ Rattus norvegicus ]
• Synonyms: Serpine1; serpinpeptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),member 1; Pai1; PAI1A; Planh; Pai1aa; RATPAI1A; plasminogen activatorinhibitor 1; PAI; PAI-1; serpin E1; endothelial plasminogen activator inhibitor;serine (or cysteine) proteinase inhibitor, member 1; serine (or cysteine)peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinaseinhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor,clade E (nexin, plasminogen activator inhibitor type 1), member 1
• Gene ID: 24617
• mRNA Refseq: NM_012620
• Protein Refseq: NP_036752
• UniProt ID: P20961
• Chromosome Location: 12q11-q12
• Function: peptidase inhibitoractivity; protease binding; receptor binding; contributes to receptorbinding; serine-type endopeptidase inhibitor activity