Recombinant Rat SIK1 Protein Pre-coupled Magnetic Beads

• Cat.No.: SIK1-5061R-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Rat
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Sik1 salt-inducible kinase 1 [ Rattus norvegicus ]
• Official Symbol: SIK1
• Gene ID: 59329
• mRNA Refseq: NM_021693.2
• Protein Refseq: NP_067725.2
• UniProt ID: Q9R1U5

Reviews

08/14/2021

Our lab swears by this product! It's a versatile and reliable tool for our experiments.

06/05/2019

The quality control is evident in the data precision we achieve.

12/09/2018

As a researcher, I can't live without this product. Makes my experiments more accurate and efficient.

Q&As

What is the significance of SIK1 dysregulation in the context of cancer, and how does it impact cell proliferation and survival?

Dysregulation of SIK1 has been implicated in cancer. It can influence cell proliferation and survival by affecting the activity of transcription factors involved in cell cycle control and apoptosis.

How does SIK1 contribute to the regulation of adipose tissue metabolism, and what implications does this have for metabolic disorders?

SIK1 plays a role in adipose tissue metabolism by modulating the activity of transcription factors involved in lipogenesis and lipolysis. Dysregulation may contribute to metabolic disorders like obesity and insulin resistance.

What is the primary function of the SIK1 protein in cellular processes?

SIK1, or Salt-Inducible Kinase 1, is involved in the regulation of cellular responses to various stimuli, including stress, metabolism, and inflammation.

How does SIK1 participate in cellular energy homeostasis, and what are its downstream targets in metabolic pathways?

SIK1 regulates energy homeostasis by phosphorylating and modulating the activity of key metabolic regulators, such as cAMP response element-binding protein (CREB) and class IIa histone deacetylases.

How does SIK1 contribute to cellular responses to environmental stress, and what are the molecular mechanisms involved in stress signaling pathways?

SIK1 is activated in response to environmental stressors, such as osmotic stress. It regulates stress signaling pathways through the phosphorylation of downstream effectors, modulating cellular stress responses.