Active Recombinant Rhesus IGFBP2 Protein, His-tagged

• Cat.No.: IGFBP2-1188R
• Product Overview: Recombinant rhesus IGFBP2 (XP_001087071.1) (Met1-Gln324) was expressed, fused with a polyhistidine tag at the C-terminus.

Specification

• Source: HEK293
• Species: Rhesus
• Tag: His
• Predicted N Terminal: Glu 38
• Form: Lyophilized from sterile PBS, pH 7.4, 5%~8% trehalose and mannitol.
• Bio-activity: Measured by its ability to inhibit the biological activity of IGFI or IGFII on MCF7 human breast adenocarcinoma cells. The ED50 for this effect is typically 0.02-0.1 μg/mL in the presence of 14 ng/mL human IGFII.
• Molecular Mass: The recombinant rhesus IGFBP2 comprises 300 amino acids and has a calculated molecular mass of 32.8 KDa.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >67 % as determined by SDS-PAGE.
• Stability: Samples are stable for up to twelve months from date of receipt at -70ºC.
• Storage: Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: IGFBP2 insulin like growth factor binding protein 2 [ Macaca mulatta ]
• Official Symbol: IGFBP2
• Synonyms: insulin-like growth factor binding protein 2, 36kDa
• Gene ID: 696214
• Chromosome Location: chromosome: 12

Reviews

01/02/2023

Whether it's protein quantification, structural analysis, or Western Blotting, the IGFBP2 protein has consistently delivered exceptional results, earning my highest recommendation.

06/29/2016

The IGFBP2 protein has proven invaluable in protein electron microscopy structure analysis, allowing for detailed investigations and providing critical insights.

04/07/2016

Its remarkable performance in ELISA, protein electron microscopy structure analysis, and Western Blotting sets it apart as a top recommendation.

Q&As

How can IGFBP2 levels be measured in clinical settings?

IGFBP2 levels can be measured using various laboratory techniques, including ELISA (Enzyme-Linked Immunosorbent Assay) and Western blotting.

Are there other diseases where IGFBP2 plays a significant role?

Yes, IGFBP2 has been implicated in neurological disorders and metabolic diseases, making it a potential target for therapeutic interventions in these conditions.

Are there genetic variations in IGFBP2 that influence its clinical significance?

Genetic variations in the IGFBP2 gene have been identified and may contribute to individual differences in disease susceptibility and treatment responses.

How does IGFBP2 interact with insulin-like growth factors?

IGFBP2 binds to insulin-like growth factors, regulating their bioavailability and modulating their effects on cell growth and survival.

Can IGFBP2 be used as a diagnostic marker for early cancer detection?

Research suggests that elevated levels of IGFBP2 may serve as a diagnostic marker for early cancer detection, but more studies are needed to validate its clinical utility.