Recombinant Rhesus monkey APH1A Protein, His-tagged

• Cat.No.: APH1A-355R
• Product Overview: Recombinant Rhesus monkey APH1A full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Rhesus monkey
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: APH1A anterior pharynx defective 1 homolog A (C. elegans) [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: APH1A
• Synonyms: APH1A; anterior pharynx defective 1 homolog A; gamma-secretase subunit APH-1A
• Gene ID: 706483
• mRNA Refseq: NM_001266040
• Protein Refseq: NP_001252969
• UniProt ID: G7MDH0

Reviews

09/11/2022

APH1A they produced were structurally stable and not prone to mutation.

01/06/2021

The production process of APH1A is truly green and environmentally friendly, without any negative impact on the environment, and meets the requirements of environmental protection regulations.

08/27/2019

This advantage of short half-life and high clearance allows APH1A to still act quickly in medical emergencies.

Q&As

What is the prospect of APH1A in disease treatment?

APH1A is related to Alzheimer's disease and other diseases, and has certain research and application prospects for the treatment of related diseases.

What is the effect of APH1A on cell signaling?

APH1A s are involved in the formation of gamma secretase complexes that regulate cell signaling pathways.

What is the relationship between APH1A and other neurorelated proteins?

APH1A s interact with other gamma-secretase complex members, such as PS1 and Nct, to jointly regulate signaling in cells.

What is the relationship between APH1A and amyloid beta?

APH1A s, together with the gamma secretase complex, are involved in the production and metabolism of amyloid beta.

What are the major breakthroughs in the structural analysis of APH1A ?

At present, the structural analysis of APH1A is relatively limited, but future studies may have important breakthroughs.

How do APH1A s interact with other proteins?

APH1A s are involved in the assembly of the gamma secretase complex, interacting with other members such as PS1 and Nct to achieve complex formation.

What is the significance of APH1A research for understanding the pathogenesis of Alzheimer's disease?

Studying the APH1A could help to understand how dysfunction of the gamma secretase complex contributes to the development of Alzheimer's disease.

What is the relationship between APH1A and Alzheimer's disease?

The dysfunction of APH1A and γ-secretase complex is closely related to Alzheimer's disease.

What are the structural characteristics of APH1A ?

The APH1A is a single membrane protein with a transmembrane structure.

Is the loss of function of APH1A reversible?

The feasibility of functional loss repair depends on the specific degree and mechanism of loss, and the research is still in progress.

Is the expression level of APH1A correlated with certain diseases?

Yes, low APH1A expression is associated with some neurodegenerative diseases such as Alzheimer's disease.

What are the synthesis and purification methods of APH1A ?

APH1A can be synthesized by genetic engineering and purified by mass spectrometry, column chromatography and other techniques.

What are the applications of antibodies to APH1A in clinical disease diagnosis?

Antibodies to APH1A can be used to detect APH1A expression levels, which is helpful in the diagnosis of some neurodegenerative diseases.

What is the relationship between APH1A and memory function?

APH1A participates in the function of γ-secreting enzyme complex, regulates the metabolism of amyloid beta, and is associated with memory function to some extent.

How many subtypes of APH1A exist?

There are several subtypes of APH1A s, including APH1A-1 and APH1A-2.

What are the clinical applications of APH1A ?

APH1A s can be used to treat diseases associated with gamma secretase complexes, such as Alzheimer's disease.

What is the role of APH1A knockout model in research?

Knockout models of APH1A s can be used to validate the role of APH1A in physiological and pathological processes and deepen our understanding of its function.

Can APH1A mutations cause disease?

Yes, mutations in the APH1A may lead to dysfunction of the gamma secretase complex, leading to the development of related diseases.

What role does APH1A play in the development of the nervous system?

APH1A plays an important role in regulating protein complex assembly and signaling in nervous system development.

What are the possible side effects of APH1A ?

Side effects of APH1A s include possible adverse reactions during treatment and other physiological changes associated with the gamma-secretase complex.