Recombinant Saccharomyces cerevisiae YPR1 Protein (P2-Q312), His/Strep tagged

• Cat.No.: YPR1-0138H
• Product Overview: Recombinant Saccharomyces cerevisiae 6His-strepII-TEV-GG-YPR1(P2-Q312 end) Protein was expressed in E. coli.

Specification

• Description: Enables alditol:NADP+ 1-oxidoreductase activity and carbonyl reductase (NADPH) activity. Involved in D-xylose catabolic process; arabinose catabolic process; and cellular response to oxidative stress. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B).
• Source: E. coli
• Species: Saccharomyces cerevisiae
• Tag: His/Strep
• Form: Liquid
• Protein Length: P2-Q312
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: YPR1 trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1 [ Saccharomyces cerevisiae S288C ]
• Official Symbol: YPR1
• Synonyms: YPR1; trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1; trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1; NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; human homolog AKR1B1 can complement yeast null mutant
• Gene ID: 851974
• mRNA Refseq: NM_001180676
• Protein Refseq: NP_010656
• UniProt ID: Q12458