Recombinant Zebrafish ADIPOR1A

• Cat.No.: ADIPOR1A-597Z
• Product Overview: Recombinant Zebrafish ADIPOR1A full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: adipor1a adiponectin receptor 1a [ Danio rerio (zebrafish) ]
• Official Symbol: ADIPOR1A
• Gene ID: 436740
• mRNA Refseq: NM_001002467
• Protein Refseq: NP_001002467
• UniProt ID: Q6DGJ5

Reviews

11/06/2022

The technical support provided by the manufacturer was outstanding and swiftly resolved the issue that I was facing.

01/26/2018

I am thoroughly impressed with the overall experience and am assured that this protein will significantly enhance the success of my research.

01/22/2017

I am also pleased with the easy-to-follow instructions provided with the protein, making it simple to handle and prepare for use in my experiments.

10/18/2016

The ADIPOR1A protein that I received is of exceptional quality and perfectly suits my experimental requirements.

Q&As

Can lifestyle factors affect ADIPOR1A expression?

Yes, lifestyle factors such as diet and physical activity have been shown to affect ADIPOR1A expression and function. A healthy diet and regular exercise can increase adiponectin levels and enhance adiponectin receptor signaling, potentially improving metabolic health and reducing the risk of metabolic diseases.

Is there a link between ADIPOR1A and cancer?

Research suggests that ADIPOR1A may play a role in the pathogenesis of various types of cancer, including breast, colon, and prostate cancer. Studies have shown that adiponectin, through its interactions with ADIPOR1A, may have anti-cancer effects by inhibiting cell growth and promoting apoptosis.

Can ADIPOR1A be used as a biomarker for metabolic diseases?

As ADIPOR1A is involved in the regulation of glucose and lipid metabolism, it has been proposed as a potential biomarker for metabolic diseases such as type 2 diabetes and cardiovascular disease. However, further research is needed to confirm its potential as a biomarker.

Are there any medications that target ADIPOR1A?

Currently, there are no medications that directly target ADIPOR1A. However, some drugs used to treat metabolic diseases, such as thiazolidinediones, have been shown to improve adiponectin signaling and may indirectly activate ADIPOR1A.

What other health conditions are associated with ADIPOR1A dysfunction?

associated with ADIPOR1A dysfunction? In addition to metabolic diseases such as type 2 diabetes and cardiovascular disease, ADIPOR1A dysfunction has been associated with other health conditions. For instance, it has been linked to certain cancers, including breast and colon cancer, as well as infertility and polycystic ovary syndrome (PCOS).

Does ADIPOR1A play a role in inflammation?

Yes, ADIPOR1A has been shown to play a role in regulating inflammation through its interactions with adiponectin. Activation of ADIPOR1A can suppress inflammatory signaling pathways, while deficiency or dysfunction of this receptor may contribute to chronic inflammation and inflammation-related diseases.

Can ADIPOR1A dysfunction be treated with gene therapy?

Gene therapy is a promising approach for treating genetic disorders, but currently, there are no approved clinical gene therapies specifically targeting ADIPOR1A dysfunction. However, preclinical studies have shown the potential of using gene therapy to restore ADIPOR1A expression and function, providing possible future avenues for therapeutic intervention.

Can ADIPOR1A testing provide personalized treatment options?

Identifying ADIPOR1A dysfunction or deficiency through genetic testing or other diagnostic methods may provide personalized treatment options for metabolic diseases. For example, individuals with specific ADIPOR1A mutations may benefit from targeted therapies or lifestyle interventions tailored to their individual risk factors.

Is there a genetic component to ADIPOR1A dysfunction?

Yes, genetic mutations and variations in the ADIPOR1A gene have been associated with dysfunction or deficiency of the receptor, which may contribute to the development of metabolic diseases such as type 2 diabetes and cardiovascular disease.

How is ADIPOR1A related to insulin resistance?

ADIPOR1A plays a key role in regulating insulin sensitivity, and dysfunction or deficiency of this receptor may contribute to the development of insulin resistance. Studies have shown that genetic variations in the ADIPOR1A gene may be associated with increased risk of insulin resistance and type 2 diabetes.

How does ADIPOR1A interact with other molecules in the body?

ADIPOR1A interacts with other molecules in various pathways in the body. It interacts with adiponectin, which regulates glucose and lipid metabolism, as well as with other adipokines such as leptin and resistin. It is also involved in inflammation and immune responses through its interactions with cytokines and chemokines.

Are there any risks associated with ADIPOR1A-targeted therapies?

As with any therapeutic intervention, there are potential risks associated with ADIPOR1A-targeted therapies. For example, activation of ADIPOR1A may have side effects such as hypoglycemia, and long-term effects of altering adiponectin receptor signaling are not well understood.

Can ADIPOR1A be targeted for cancer therapy?

Although further research is needed, ADIPOR1A has been proposed as a potential therapeutic target for cancer. Activation of ADIPOR1A may inhibit tumor growth and promote cancer cell death, making it an attractive target for the development of novel cancer therapies.

Can lifestyle factors influence ADIPOR1A expression and function?

ADIPOR1A expression and function? Yes, lifestyle factors such as physical activity, diet, and weight loss have been shown to influence ADIPOR1A expression and function. For instance, exercise has been found to enhance ADIPOR1A expression, while a high-fat diet and obesity have been linked to ADIPOR1A dysfunction.

Can ADIPOR1A dysfunction be linked to obesity and weight gain?

Yes, ADIPOR1A dysfunction has been linked to obesity and weight gain as it plays a critical role in adiponectin signaling, which regulates energy metabolism, glucose uptake, and lipolysis. Studies have found that individuals with ADIPOR1A dysfunction have impaired glucose metabolism and a higher risk of developing obesity.

How can ADIPOR1A be measured in the laboratory?

ADIPOR1A expression and activity can be measured in the laboratory using a variety of techniques, such as western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA).